Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Central neural pathways for angiotensin-induced thirst.

G J Mogenson, J Kucharczyk

    Federation Proceedings
    |November 1, 1978
    PubMed
    Summary

    The preoptic region is involved in angiotensin-induced thirst. Separate neural pathways in the hypothalamus may mediate intracellular and extracellular thirst signals.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Sleeve gastrectomy and Roux-en-Y gastric bypass exhibit differential effects on food preferences, nutrient absorption and energy expenditure in obese rats.

    International journal of obesity (2005)·2012
    Same author

    Minimally invasive procedures. Interventional MR image-guided functional neurosurgery.

    Neuroimaging clinics of North America·2002
    Same author

    Minimally invasive procedures. Advances in image-guided delivery of drug and cell therapies into the central nervous system.

    Neuroimaging clinics of North America·2002
    Same author

    Cost-efficacy of MR-guided neurointerventions.

    Neuroimaging clinics of North America·2002
    Same author

    Visualization of nonstructural changes in early white matter development on diffusion-weighted MR images: evidence supporting premyelination anisotropy.

    AJNR. American journal of neuroradiology·2001
    Same author

    Perfusion MR neuroimaging in patients undergoing balloon test occlusion of the internal carotid artery.

    AJNR. American journal of neuroradiology·2001

    Area of Science:

    • Neuroscience
    • Neurobiology
    • Physiology

    Background:

    • The preoptic region plays a role in regulating thirst.
    • Angiotensin II is a key hormone involved in thirst regulation.

    Purpose of the Study:

    • To investigate the neural pathways involved in angiotensin-induced thirst originating from the preoptic region.
    • To differentiate between pathways for intracellular and extracellular thirst signals.

    Main Methods:

    • Behavioral, electrophysiological, and autoradiographic mapping techniques were used.
    • Lesion studies in specific brain regions (medial hypothalamus, midbrain, lateral hypothalamus) were performed.
    • Microinjections of angiotensin II and hypertonic saline were administered.

    Main Results:

    • The most responsive area for angiotensin-induced thirst is at the caudal medial preoptic region/rostral anterior hypothalamus.
    • A specific neural pathway involving the medial forebrain bundle, midlateral hypothalamus, and paramedial midbrain tegmentum was identified for preoptic angiotensin II-induced thirst.
    • Lesions along this pathway attenuated drinking, but not water intake from other angiotensin II sites (subfornical organ, ventricles).
    • Separate pathways appear to mediate intracellular and extracellular thirst signals in the hypothalamus.

    Conclusions:

    • The medial forebrain bundle is implicated in thirst pathways from the preoptic area but not from other central sites.
    • Distinct neural circuits in the hypothalamus likely process different types of thirst stimuli.

    Related Experiment Videos