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Updated: Jun 4, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Changing methods for discovering antiviral drugs.

¹Roche Research Centre, Welwyn Garden City, UK.

Methods in Molecular Medicine

|February 19, 2011

Summary

Antiviral drug discovery has advanced significantly, moving from broad screening to sophisticated, mechanism-based approaches. This evolution is crucial for combating emerging viral diseases and drug resistance.

Area of Science:

Virology
Pharmacology
Drug Discovery

Background:

Viral diseases were once largely untreatable, significantly impacting patient quality of life.
The emergence of new viral diseases and drug resistance necessitates continuous antiviral drug discovery.
Antiviral therapy has seen dramatic advancements in drug discovery approaches over the last 40 years.

Purpose of the Study:

To document the evolution of antiviral drug discovery methodologies.
To highlight the shift from traditional screening to modern, mechanism-based drug design.

Main Methods:

Historical overview of antiviral drug discovery techniques.
Comparison of early broad screening methods (in animals and tissue culture) with contemporary approaches.
Discussion of mechanism-based drug discovery utilizing computer-assisted techniques and biostructural information.

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Last Updated: Jun 4, 2026

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Assays for the Identification of Novel Antivirals against Bluetongue Virus

Published on: October 11, 2013

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Early Viral Entry Assays for the Identification and Evaluation of Antiviral Compounds

Published on: October 29, 2015

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses

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Published on: May 5, 2014

Main Results:

Antiviral therapies have progressed from largely ineffective to safe and effective treatments.
Drug discovery processes have transformed, particularly within antiviral therapy.
Modern methods offer more targeted and efficient identification of active antiviral agents.

Conclusions:

The field of antiviral drug discovery has undergone a revolution in methodology.
Continued innovation in drug discovery is essential to address ongoing viral threats and resistance.
Mechanism-based approaches represent a significant leap forward in developing new antiviral therapies.