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Urinary UMOD excretion and chronic kidney disease in gout patients: cross-sectional case-control study

Chien-Hsing Wu1, Chien-Te Lee, Chih-Hsiung Lee

  • 1Division of Nephrology, Chang Gung Memorial Hospital--Kaohsiung Medical Center, Chang Gung University College of Medicine, Kaohsiung, Taiwan.

Renal Failure
|February 22, 2011
PubMed

Insights

Urinary uromodulin (UMOD) levels are lower in gout patients with chronic kidney disease (CKD). Lower UMOD excretion is linked to reduced kidney function in gout patients, suggesting UMOD

Area of Science:

  • Nephrology
  • Rheumatology
  • Biochemistry

Background:

  • Gout and chronic kidney disease (CKD) frequently coexist, but their relationship remains poorly understood.
  • Previous research suggests a link between diminished urinary uromodulin (UMOD) excretion and CKD in patients with diabetes and lupus.

Purpose of the Study:

  • To investigate the association between urinary UMOD excretion and the presence of CKD in patients diagnosed with gout.

Main Methods:

  • Study included 53 Taiwanese gout patients with stable disease activity, categorized into CKD (n=25) and non-CKD (n=28) groups.
  • Pearson correlation analysis assessed the relationship between urinary UMOD excretion and estimated glomerular filtration rate (eGFR).
  • Multivariate analysis examined factors associated with CKD in gout patients, including urinary UMOD levels, age, and uric acid.

Main Results:

  • Urinary UMOD excretion showed a significant positive correlation with eGFR (p=0.004).
  • Patients with both gout and CKD exhibited lower urinary UMOD excretion compared to those with gout alone (OR: 0.826, p<0.001).
  • Older age and higher uric acid levels were significantly associated with the presence of CKD in gout patients (p<0.001 for both).

Conclusions:

  • This study suggests that uromodulin may play a role in the complex relationship between gout and chronic kidney disease.
  • Lower urinary UMOD excretion is a potential biomarker for CKD in gout patients.
  • Further research, including animal models, is warranted to elucidate the mechanistic link between UMOD, gout, and CKD.

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