Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Search research articles

Related Experiment Videos

Plasminogen activators and cancer.

¹Nuclear Medicine Department, St Vincent's Hospital, Dublin, Republic of Ireland.

Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis

|December 1, 1990

Summary

This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Correction: Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells.

British journal of cancer·2025

Same author

A zinc phthalocyanine-benzoperylenetriimide conjugate for solvent dependent ultrafast energy vs. electron transfer.

Chemical communications (Cambridge, England)·2019

Same author

Trends in vitamin D supplement use in a general female and breast cancer population in Ireland: A repeated cross-sectional study.

PloS one·2018

Same author

Clinical use of biomarkers in breast cancer: Updated guidelines from the European Group on Tumor Markers (EGTM).

European journal of cancer (Oxford, England : 1990)·2017

Same author

Mutant p53: a novel target for the treatment of patients with triple-negative breast cancer?

International journal of cancer·2016

Same author

Targeting ADAM-17 with an inhibitory monoclonal antibody has antitumour effects in triple-negative breast cancer cells.

British journal of cancer·2015

Same journal

Pampiniform venous plexus thrombosis in a 37 years-old male patient with severe thrombocytosis: a multifactorial aetiology.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026

Same journal

PROS1 Cys475Tyr mutation associated with a type III protein S deficiency pattern.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026

Same journal

Dynamic microclot profiling: thromboelastography advances precision management in long COVID and myalgic encephalomyelitis/chronic fatigue syndrome.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026

Same journal

Genetic characterization of Glanzmann thrombasthenia: insights from novel igta2b mutations in a Tunisian patient cohort.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026

Same journal

Uterine fibroids as an underrecognized risk factor for venous thromboembolism: a narrative review.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026

Same journal

SEER sonorheometry enhances fibrinolysis detection during liver transplantation with heparin.

Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis·2026

See all related articles

Urokinase-type plasminogen activator (uPA) is linked to cancer metastasis and poor prognosis in breast cancer patients. Inhibiting uPA may offer a therapeutic strategy for anti-metastatic agents.

Area of Science:

Biochemistry
Molecular Biology
Oncology

Background:

Plasminogen activators (PAs) are serine proteases converting plasminogen to plasmin.
Tissue-type PA (tPA) and urokinase-type PA (uPA) are the main forms.
Malignant cells often exhibit increased uPA production.

Purpose of the Study:

To investigate the role of uPA in cancer metastasis.
To explore uPA as a prognostic marker in breast cancer.
To identify uPA as a potential target for anti-metastatic therapies.

Main Methods:

Enzyme activity assays
Expression level analysis
Receptor binding studies

Main Results:

Related Experiment Videos

Elevated uPA levels correlate with increased metastatic potential.
High uPA expression in breast cancers indicates a poor prognosis.
uPA's involvement in the metastatic cascade is increasingly evident.

Conclusions:

uPA plays a direct role in cancer metastasis.
uPA serves as a significant prognostic biomarker for breast cancer.
Targeting uPA presents a promising strategy for developing anti-metastatic agents.