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Updated: Aug 11, 2026

In Vitro and In Vivo Model to Study Bacterial Adhesion to the Vessel Wall Under Flow Conditions
Published on: June 11, 2015
Endotoxin, PAF and arterial thrombosis
R H Bourgain1, R Andries, P Braquet
1Laboratory of Physiology and Physiopathology, Free University of Brussels, Belgium.
Abstract:
Using an optoelectronic device, we demonstrated that endotoxin modulates platelet-activating factor (PAF)-induced arterial thrombosis in a mesenteric artery of the guinea-pig. Indeed, topical superfusion by PAF induces the generation of platelet-vessel wall interactions, invariably followed by thrombus formation. A low dose of endotoxin markedly increased, while a high dose significantly reduced thrombus formation. The reducing effect of the high dose can be completely offset by indometacin, indicating the involvement of prostaglandin I2.
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