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Multidrug-resistant tuberculosis is associated with low plasma concentrations of human neutrophil peptides 1-3

L-M Zhu1, C-H Liu, P Chen

  • 1Department of Respiratory Medicine, The Second Xiangya Hospital of Central South University, Changsha, Hunan, People's Republic of China.

The International Journal of Tuberculosis and Lung Disease : the Official Journal of the International Union Against Tuberculosis and Lung Disease
|February 22, 2011
PubMed
Abstract

Insights

Multidrug-resistant tuberculosis (MDR-TB) is linked to lower levels of human neutrophil peptides 1-3 (HNP1-3). Plasma HNP1-3 concentrations increased after treatment but remained below healthy controls.

Area of Science:

  • Infectious Diseases
  • Immunology
  • Microbiology

Background:

  • Human neutrophil peptides 1-3 (HNP1-3) are crucial for innate immunity.
  • These peptides may play a role in the development of multidrug-resistant tuberculosis (MDR-TB).

Purpose of the Study:

  • To examine the association between HNP1-3 levels and MDR-TB.
  • To compare HNP1-3 concentrations in drug-susceptible TB and MDR-TB patients.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure plasma HNP1-3 concentrations in 42 patients (21 drug-susceptible TB, 21 MDR-TB) and healthy controls.
  • Measurements were taken before treatment and at 6, 18, and 24 months post-treatment.
  • Mycobacterium tuberculosis duration in sputum and peripheral blood neutrophil counts were also assessed.

Main Results:

  • Pre-treatment HNP1-3 levels were lower in MDR-TB patients compared to drug-susceptible TB patients and healthy controls.
  • Post-treatment HNP1-3 levels increased in MDR-TB patients but remained lower than in controls.
  • HNP1-3 concentration showed a negative correlation with M. tuberculosis duration in sputum and a positive correlation with neutrophil counts.

Conclusions:

  • Low plasma concentrations of HNP1-3 are associated with MDR-TB.
  • HNP1-3 may serve as a potential biomarker for MDR-TB.

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