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A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

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Published on: March 14, 2025

[Strontium ranelate-induced DRESS syndrome].

M Le Merlouette1, H Adamski, M Dinulescu

  • 1Service de dermatologie, CHU Pontchaillou, rue H.-Le-Guilloux, 35033 Rennes cedex, France.

Annales De Dermatologie Et De Venereologie
|February 22, 2011
PubMed
Summary
This summary is machine-generated.

Strontium ranelate can cause severe drug reactions with eosinophilia and systemic symptoms (DRESS). This case highlights a rare complication of linear IgA bullous dermatosis from vancomycin, emphasizing the need for vigilance with osteoporosis treatments.

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Last Updated: Jun 4, 2026

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis
07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

Area of Science:

  • Dermatology
  • Pharmacology
  • Internal Medicine

Background:

  • Drug reaction with eosinophilia and systemic symptoms (DRESS) is a severe adverse drug reaction.
  • Strontium ranelate is a medication approved for postmenopausal osteoporosis.
  • DRESS syndrome carries a significant risk, with reported fatalities.

Observation:

  • A 77-year-old woman developed DRESS after 4 weeks of strontium ranelate treatment for osteoporosis.
  • The patient later developed linear IgA bullous dermatosis while treated with vancomycin for MRSA bacteraemia.
  • Both conditions resolved after discontinuation of the respective causative agents.

Findings:

  • Strontium ranelate-induced DRESS syndrome was diagnosed based on clinical presentation and laboratory findings.
  • Vancomycin was identified as the cause of a secondary linear IgA bullous dermatosis.
  • Complete resolution of both dermatological conditions was achieved.

Implications:

  • Healthcare authorities have issued warnings regarding strontium ranelate and DRESS syndrome risk.
  • This case underscores the importance of recognizing severe cutaneous reactions to strontium ranelate.
  • Co-occurrence of DRESS and vancomycin-induced linear IgA bullous dermatosis presents a diagnostic challenge.