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Related Concept Videos

Inflammation01:38

Inflammation

Overview
Defense Mechanism Against Infection01:26

Defense Mechanism Against Infection

Natural flora, body system defenses, and inflammation are natural barriers of the body against infectious agents regardless of previous exposure. Normal floras of the human body refer to the microbial population that colonizes the skin and mucous membranes.
In addition, many body organ systems have unique defenses against infection. The skin is an intact, multilayered surface preventing invasion by microorganisms unless impaired. Mucous membranes lining the mouth, nose, and eyelids are barriers...
Chronic Inflammation: Introduction01:12

Chronic Inflammation: Introduction

Chronic inflammation is a prolonged, dysregulated immune response that persists for weeks to years when the inciting stimulus is difficult to eradicate or when self‑antigens drive ongoing reactivity. Morphologically, it is defined by mononuclear cell infiltration, progressive tissue destruction, and concurrent attempts at healing via angiogenesis and fibrosis. Compared with acute inflammation, edema is less prominent while cellular infiltration predominates; triggers include persistent...
Inflammation: Introduction01:28

Inflammation: Introduction

Inflammation is a fundamental, protective biological response of vascularized tissues to cellular injury, infection, or harmful stimuli. Its primary function is to eliminate the initial cause of injury, clear necrotic cells and damaged tissue, and initiate the necessary repair processes.Cardinal SignsAcute inflammation presents with classic signs. Redness results from vasodilation and increased blood flow. Heat is due to increased metabolism and circulation. Swelling results from the...
Inflammatory Response I: Vascular and Cellular01:30

Inflammatory Response I: Vascular and Cellular

The inflammatory response is the body's defense against infection, injury, or irritation from bacteria, trauma, toxins, or heat. Inflammation helps locate and destroy pathogens and remove damaged tissue elements to heal the body. During this initial phase, fluid, blood products, and nutrients migrate to the injured area, resulting in redness, heat, swelling, ache, and loss of function. Moreover, signs of systemic inflammation include fever, increased WBC count, malaise, anorexia, nausea,...
Inflammatory Response01:28

Inflammatory Response

An inflammatory response is a localized, nonspecific immune reaction that occurs when a tissue is injured. It is characterized by redness, swelling, heat, and pain, which are commonly called the cardinal signs and symptoms of inflammation. Inflammation can sometimes result in a loss of function.
Inflammation can be triggered by various stimuli, such as impact, abrasion, chemical irritation, infections, and extreme hot or cold temperatures. These can damage cells and connective tissue fibers,...

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Related Experiment Video

Updated: Jun 4, 2026

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

Inflammation and microflora.

Mark Pimentel1, Christopher Chang

  • 1GI Motility Program, Cedars-Sinai Medical Center, 8730 Alden Drive, Suite 225E, Los Angeles, CA 90048, USA. pimentelm@cshs.org

Gastroenterology Clinics of North America
|February 22, 2011
PubMed
Summary
This summary is machine-generated.

Irritable bowel syndrome (IBS) may stem from changes in gut bacteria. This review explores the evidence for a bacterial theory and its link to inflammation in IBS patients.

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A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Related Experiment Videos

Last Updated: Jun 4, 2026

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach
08:24

Injections of Lipopolysaccharide into Mice to Mimic Entrance of Microbial-derived Products After Intestinal Barrier Breach

Published on: May 2, 2018

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites
09:52

A Mouse Model for Pathogen-induced Chronic Inflammation at Local and Systemic Sites

Published on: August 8, 2014

Area of Science:

  • Gastroenterology
  • Microbiology
  • Immunology

Background:

  • Irritable bowel syndrome (IBS) is a prevalent gastrointestinal disorder affecting 10-20% of adults.
  • Emerging evidence suggests a link between IBS and alterations in the gut microbiome.
  • The pathophysiology of IBS is not fully understood, necessitating new hypotheses.

Purpose of the Study:

  • To review the evidence supporting a bacterial etiology for IBS.
  • To propose a hypothesis integrating gut bacteria into IBS pathophysiology.
  • To examine the interaction between gut microbiota and inflammation in IBS.

Main Methods:

  • Literature review of studies on IBS and gut microbiota.
  • Synthesis of existing data to formulate a novel hypothesis.
  • Analysis of research linking gut flora to inflammatory processes in IBS.

Main Results:

  • Growing evidence supports the role of intestinal bacterial composition in IBS.
  • A hypothesis is formulated on how bacterial systems contribute to IBS development.
  • Data indicates a connection between gut flora and inflammation in IBS.

Conclusions:

  • Altered intestinal bacterial composition is a plausible factor in IBS.
  • Gut microbiota may play a central role in the pathophysiology of IBS.
  • The interplay between gut bacteria and inflammation warrants further investigation in IBS.