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Related Concept Videos

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care01:30

Urinary Tract Infection III: Diagnostic Studies and Interprofessional Care

A healthcare provider can diagnose a urinary tract infection (UTI) through several methods:Medical History and Symptoms: The provider will take a detailed medical history and ask about symptoms such as frequent urination, burning sensation during urination, and lower abdominal pain.Urinalysis: A clean-catch urine sample is collected in a sterile container and tested for the presence of bacteria, white blood cells (leukocytes), nitrites, blood, and protein. The presence of leukocytes and...
Urinary Tract Calculi III: Medical Management01:30

Urinary Tract Calculi III: Medical Management

The diagnosis of renal calculi involves several imaging techniques, including non-contrast CT scans and ultrasound. These methods help visualize kidney stones, assess their size and location, and detect possible obstructions. Additionally, Measuring urine pH is useful for diagnosing specific stone types, such as struvite (alkaline pH) and uric acid stones (acidic pH). Cystine stones are primarily linked to cystinuria, a genetic condition. A urinalysis helps detect blood in the urine (hematuria)...
Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations01:26

Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations

Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
Imaging Studies IV: Magnetic Resonance Imaging01:27

Imaging Studies IV: Magnetic Resonance Imaging

Introduction:Magnetic Resonance Imaging, or MRI, can include a specialized imaging technique of the urinary system known as Magnetic Resonance Urography (MRU). This radiation-free technique uses strong magnetic fields and radio waves to produce detailed images with the help of a computer. MRU is particularly effective for visualizing fluid-filled structures like the kidneys, ureters, and bladder.Applications of MRI in the Genitourinary SystemKidneys and Ureters: MRI detects tumors, cysts,...

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Related Experiment Video

Updated: Jun 4, 2026

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
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A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

Urinary PCA3 score predicts prostate cancer multifocality.

Virginie Vlaeminck-Guillem1, Marian Devonec, Marc Colombel

  • 1Department of Medical Unit of Molecular Oncology and Transfer, Medical Faculty of Lyon 1 University, Lyon, France.

The Journal of Urology
|February 22, 2011
PubMed
Summary
This summary is machine-generated.

The urinary PCA3 gene test score correlates with prostate cancer tumor volume and multifocality. This finding may help select patients for active surveillance or focal therapy based on prostate cancer characteristics.

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Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
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Last Updated: Jun 4, 2026

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound
06:08

A Cognitive Fusion-guided Prostate Biopsy Using Multiparametric Magnetic Resonance Imaging and Transrectal Ultrasound

Published on: March 21, 2025

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy
09:11

Use of MRI-ultrasound Fusion to Achieve Targeted Prostate Biopsy

Published on: April 9, 2019

Area of Science:

  • Urology
  • Oncology
  • Molecular Diagnostics

Background:

  • The urinary PCA3 gene test aids in prostate cancer diagnosis and re-biopsy decisions.
  • Understanding factors influencing PCA3 shedding is crucial for accurate interpretation.

Purpose of the Study:

  • To identify pathological features affecting urinary PCA3 gene expression in prostate cancer patients.
  • To correlate PCA3 scores with histopathological findings post-prostatectomy.

Main Methods:

  • Analyzed PCA3 scores from 102 radical prostatectomy patients using the Progensa® PCA3 assay.
  • Evaluated correlations between PCA3 scores and tumor site, number of foci, tumor volume, Gleason score, and pathological stage.

Main Results:

  • PCA3 score significantly correlated with total tumor volume (p <0.001).
  • PCA3 score showed positive correlations with apical/basal invasion, bilaterality, and multifocality.
  • Multifocality independently influenced PCA3 score on multivariate analysis (p = 0.012).

Conclusions:

  • Prostate tumor site and number of foci influence urinary PCA3 scores.
  • PCA3 testing may help identify patients with unifocal, unilateral cancer suitable for active surveillance or focal therapy.