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Updated: Jun 4, 2026

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Digital Home-Monitoring of Patients after Kidney Transplantation: The MACCS Platform

Published on: April 12, 2021

Immunosuppression after kidney transplantation.

L P Kihm¹, M Zeier, C Morath

¹Department of Nephrology, University Hospital, Heidelberg, Germany. lars.kihm@med.uni-heidelberg.de

Minerva Urologica E Nefrologica = the Italian Journal of Urology and Nephrology

|February 22, 2011

Summary

Kidney transplant rejection episodes have decreased, but long-term survival needs improvement. New immunosuppressants aim to balance rejection prevention with fewer side effects, enabling reduced corticosteroid and calcineurin inhibitor use.

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Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Trans-vivo Delayed Type Hypersensitivity Assay for Antigen Specific Regulation

Published on: May 2, 2013

Area of Science:

Nephrology
Transplantation Immunology
Pharmacology

Background:

Kidney transplantation offers good short-term success, with declining acute rejection rates.
However, significant improvements in long-term kidney allograft survival have not been achieved.
Current immunosuppressive strategies face challenges in balancing efficacy with organ-specific and systemic toxicity.

Purpose of the Study:

To evaluate the evolving landscape of immunosuppressive therapies in kidney transplantation.
To explore the potential for minimizing or avoiding corticosteroids and calcineurin inhibitors.
To address the critical need for enhanced long-term allograft survival.

Main Methods:

Review of current immunosuppressive agents and their mechanisms of action.
Analysis of trends in acute rejection episodes and long-term allograft survival.
Assessment of the feasibility of corticosteroid-sparing and calcineurin inhibitor-avoiding protocols.

Main Results:

Advancements in immunosuppressive pharmacology have introduced novel agents.
These new agents offer diverse mechanisms to combat rejection.
Minimization or avoidance of traditional agents like corticosteroids and calcineurin inhibitors is becoming increasingly viable.

Conclusions:

Optimizing immunosuppression is key to improving long-term kidney transplant outcomes.
Newer immunosuppressive drugs facilitate reduced reliance on corticosteroids and calcineurin inhibitors.
Further research is needed to fully leverage these advancements for sustained allograft function.