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Pulmonary function outcomes in bronchopulmonary dysplasia through childhood and into adulthood: implications for

Don Hayes1, J Thomas Meadows, Brian S Murphy

  • 1Department of Pediatrics, University of Kentucky College of Medicine, Kentucky Children's Hospital, Lexington, Kentucky 40536, USA. don.hayes@uky.edu

Primary Care Respiratory Journal : Journal of the General Practice Airways Group
|February 22, 2011
PubMed

Insights

Bronchopulmonary dysplasia (BPD) is a chronic lung disease in infants that can affect pulmonary function long-term. This review discusses the evolving nature of BPD and its impact on lung health through adulthood.

Area of Science:

  • Neonatal Medicine
  • Pediatric Pulmonology
  • Respiratory Physiology

Background:

  • Bronchopulmonary dysplasia (BPD) arises from prematurity and supportive care, involving factors like mechanical ventilation and infection.
  • These elements trigger chronic inflammation, leading to impaired lung development (alveolarization and vascularization) in infants.
  • Understanding the 'new' BPD is crucial as its pathophysiology and therapeutic approaches have evolved.

Purpose of the Study:

  • To review the long-term pulmonary function outcomes in individuals with BPD.
  • To inform primary care physicians about the evolving nature of BPD and its lasting effects.

Main Methods:

  • Literature review and synthesis of existing research on BPD.
  • Analysis of studies focusing on pulmonary function in older children and young adults with a history of BPD.

Main Results:

  • Individuals with BPD often experience persistent pulmonary function abnormalities into later life.
  • The 'new' BPD presents with distinct long-term respiratory challenges compared to historical BPD.

Conclusions:

  • Long-term monitoring of pulmonary function is essential for patients with a history of BPD.
  • Healthcare providers must be aware of the chronic respiratory sequelae of BPD to ensure appropriate patient management.

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