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Updated: Jun 4, 2026
13:01
Anti-Nuclear Antibody Screening Using HEp-2 Cells
Published on: June 23, 2014
Antibodies in nuclear medicine
1Department of Nuclear Medicine, New Addenbrookes Hospital, Cambridge, UK.
Methods in Molecular Medicine
|February 22, 2011
Summary
Radiolabeled antibodies serve dual roles in nuclear medicine for therapy and diagnosis. Diagnostic applications include monoclonal antibodies for disease targeting and polyclonal antibodies for imaging inflammation.
Area of Science:
- Nuclear Medicine
- Immunology
- Radiochemistry
Background:
- Radiolabeled antibodies are crucial tools in modern nuclear medicine.
- Their applications span both therapeutic and diagnostic interventions.
- Antibodies offer high specificity for targeting biological molecules.
Purpose of the Study:
- To elucidate the distinct roles of radiolabeled antibodies in nuclear medicine.
- To differentiate between diagnostic and therapeutic applications.
- To highlight the utility of monoclonal and polyclonal antibodies in imaging.
Main Methods:
- Utilizing radiolabeling techniques to attach radioactive isotopes to antibodies.
- Employing antibody-based imaging for diagnostic purposes.
- Administering radiolabeled antibodies for therapeutic interventions.
Main Results:
- Monoclonal antibodies (mAbs) are primarily used for targeted disease diagnosis.
- Polyclonal antibodies serve as intravascular reference markers.
- Polyclonal antibodies are also utilized for imaging vascular permeability in inflammatory diseases.
Conclusions:
- Radiolabeled antibodies are versatile agents in nuclear medicine.
- Monoclonal antibodies offer precise disease targeting for diagnosis.
- Polyclonal antibodies provide valuable insights into vascular dynamics and inflammation.
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