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Factors for high-risk asthma in Taiwanese children

Chieh-Han Cheng1, Shyh-Dar Shyur, Li-Hsin Huang

  • 1Division of Allergy, Immunology, Rheumatology Disease, Department of Pediatrics, Mackay Memorial Hospital, Taipei, Taiwan.

Asian Pacific Journal of Allergy and Immunology
|February 23, 2011
PubMed

Insights

Identifying high-risk asthma in children is crucial for preventing fatalities. Factors like increased severity, symptom scores, specific IgE levels, and reduced lung function indicate a higher risk in pediatric asthma patients.

Area of Science:

  • Pediatric Allergy and Immunology
  • Respiratory Medicine
  • Clinical Epidemiology

Background:

  • Asthma is a significant cause of mortality in young individuals, with potential for prevention through enhanced treatment strategies.
  • Atopic asthma in children presents a critical public health concern, necessitating identification of risk factors for adverse outcomes.
  • Understanding predictors of severe asthma is vital for timely intervention and improved patient management.

Purpose of the Study:

  • To identify factors associated with a high risk of mortality in Taiwanese children diagnosed with atopic asthma.
  • To investigate the correlation between allergy-related parameters and high-risk asthma in pediatric populations.
  • To determine the association of pulmonary function with severe asthma exacerbations in children.

Main Methods:

  • A cohort of 1,122 Taiwanese children aged 5-18 years with atopic asthma was studied.
  • Atopic asthma diagnosis was confirmed, and specific immunoglobulin E (IgE) levels to eight common allergens were measured.
  • High-risk asthma was defined by criteria including hospital admission or emergency department visits; associations with clinical and immunological markers were analyzed.

Main Results:

  • Children with higher asthma severity, symptom scores, elevated total serum IgE, and specific IgE to Dermatophagoides pteronyssinus and Dermatophagoides farinae were identified as high-risk.
  • Lower forced expiratory flow at 25-75% (FEF25-75%) was significantly associated with the high-risk asthma group.
  • Allergy-related parameters and reduced pulmonary function were key indicators differentiating high-risk from low-risk pediatric asthma patients.

Conclusions:

  • Characterization of risk factors enables the identification of high-risk asthma in Taiwanese children.
  • This identification facilitates targeted and proactive treatment strategies for children with severe atopic asthma.
  • Future research can leverage these findings to develop predictive models for asthma exacerbations in pediatric populations.
Abstract

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