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Related Concept Videos

Therapeutic Drug Monitoring: Drug Analysis Methods01:26

Therapeutic Drug Monitoring: Drug Analysis Methods

Therapeutic Drug Monitoring (TDM) is a clinical practice that measures specific drug levels in a patient's blood or body tissues to tailor drug therapy effectively. This monitoring is critical for managing drugs with narrow therapeutic indices like digoxin and phenytoin, ensuring they are both safe and effective. For instance, monitoring theophylline levels in asthma patients involves precision and sensitivity to adjust doses according to individual responses to therapy, ensuring efficacy and...
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In situ experiments, such as the Doluisio method and Single-Pass Perfusion technique, provide critical insights into drug uptake by simulating in vivo conditions for drug absorption.
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Drug concentration is the quantity of a drug present in a biological sample. Measuring drug amounts in biological samples allows the clinician to understand how a drug is absorbed, distributed, metabolized, and excreted. Samples can be obtained through invasive or non-invasive methods. Invasive techniques involve surgical or parenteral interventions to gather blood, cerebrospinal fluid, or tissue biopsy. Conversely, non-invasive approaches provide samples like urine, feces, and saliva.
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Updated: Jun 4, 2026

High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
10:17

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On-site drug testing.

O H Drummer1

  • 1Department of Forensic Medicine, Monash University, Southbank, Australia.

Bulletin on Narcotics
|February 23, 2011
PubMed
Summary
This summary is machine-generated.

Point-of-care drug testing offers rapid, presumptive results for urine and oral fluid outside the lab. This technology is crucial for workplace safety, roadside checks, and suspected impairment evaluations.

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Area of Science:

  • Forensic Toxicology
  • Analytical Chemistry
  • Occupational Health

Background:

  • Drug testing outside traditional laboratory settings has increased.
  • Point-of-care (POC) testing provides rapid, presumptive results.
  • Urine and oral fluid are common specimens for POC drug testing.

Purpose of the Study:

  • To explore the advantages of point-of-care drug testing.
  • To discuss specimen types suitable for POC analysis.
  • To address critical issues in POC drug testing implementation.

Main Methods:

  • Review of current point-of-care drug testing technologies.
  • Analysis of specimen collection and handling for POC tests.
  • Discussion of regulatory and legal considerations.

Main Results:

  • POC testing offers significant advantages in speed and accessibility.
  • Urine and oral fluid are well-suited for rapid drug screening.
  • Key considerations include appropriate cut-offs and confirmatory testing.

Conclusions:

  • Point-of-care drug testing is a valuable tool for various applications.
  • Proper implementation requires attention to cut-offs, confirmation, and legal safeguards.
  • Further research may enhance the reliability and scope of POC drug testing.