Casein-based formulations as promising controlled release drug delivery systems

Area of Science:

• Biomaterials Science
• Pharmaceutical Technology
• Protein Chemistry

Background:

• Casein is a major milk protein, widely consumed globally.
• Its unique properties make it suitable for developing advanced drug delivery systems.
• This review focuses on casein's application in associating bioactive molecules for enhanced delivery.

Purpose of the Study:

• To review methods for associating bioactive molecules with casein.
• To analyze the efficacy of these methods in modifying drug release.
• To assess the potential of casein in improving drug bioavailability.

Main Methods:

• Casein films for tablet coating.
• Casein hydrogels using genipin and transglutaminase for controlled release.
• Casein floating beads for increased gastric residence time.
• Casein microparticles and nanoparticles prepared via various crosslinking and complexation techniques.

Main Results:

• Casein can modify drug dissolution and is suitable for film coating.
• Novel hydrogels, beads, microparticles, and nanoparticles demonstrate controlled release capabilities.
• Various crosslinking and complexation methods are effective in formulating casein-based delivery systems.

Conclusions:

• Casein-based formulations are effective for controlled drug delivery.
• These formulations show potential for delivering both nutraceuticals and synthetic drugs.
• Casein offers a versatile platform for developing innovative drug delivery solutions.