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Genetic control of hepatitis A severity and susceptibility to allergy

Lucienne Chatenoud1, Jean-François Bach

  • 1Université Paris Descartes, INSERM, Paris, France.

The Journal of Clinical Investigation
|February 23, 2011
PubMed

Hepatitis A virus (HAV) usually results in asymptomatic infection or mild disease, but in a small subset of patients it can lead to severe disease and even liver failure. In this issue of the JCI, Kim et al. identify a polymorphism associated with this increased disease risk in the gene that encodes the HAV receptor--TIM1. Importantly, this TIM1 gene polymorphism protects from the development of atopic diseases in HAV-seropositive individuals.

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