A molecular basis for interactions between sleep and memory

The electrophysiological properties of the sleeping brain profoundly influence memory function in various species, yet the molecular nature by which sleep and memory interact remains unclear. We summarize work that has established the cAMP-PKA-CREB intracellular signaling pathway as a major mechanism involved in the wakeful consolidation of memory in many organisms while highlighting newer evidence that this pathway has a role in sleep regulation, sleep deprivation and potentially sleep-memory interactions. We explore the possibility that sleep might influence memory processing by reactivating the same molecular cascades first recruited during learning during a sort of "molecular replay". Lastly, we discuss how new approaches together with established techniques will aid in our understanding of the nature of sleep-memory interactions.