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Positional photocleavage control of DNA-based nanoswitches

Allen K Mok1, Nancy A Kedzierski, Paul N Chung

  • 1California State Polytechnic University Pomona, Department of Chemistry, 3801 W Temple Avenue, Pomona, CA 91768, USA.

Chemical Communications (Cambridge, England)
|February 23, 2011
PubMed

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Single-Strand DNA Binding Proteins01:03

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For successful DNA replication, the unwinding of double-stranded DNA must be accompanied by stabilization and protection of the separated single strands of the DNA. This crucial task is performed by single-strand DNA-binding (SSB) proteins. They bind to the DNA in a sequence-independent manner, which means that the nitrogenous bases of the DNA need not be present in a specific order for binding of SSB proteins to it. The binding of SSB proteins straightens single-stranded DNA (ssDNA) and makes...