Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Gastrulation

Gastrulation

Gastrulation establishes the three primary tissues of an embryo: the ectoderm, mesoderm, and endoderm. This developmental process relies on a series of intricate cellular movements, which in humans transforms a flat, “bilaminar disc” composed of two cell sheets into a three-tiered structure. In the resulting embryo, the endoderm serves as the bottom layer, and stacked directly above it is the intermediate mesoderm, and then the uppermost ectoderm. Respectively, these tissue strata will form...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Improving arterial prosthesis neo-endothelialization: application of a proactive VEGF construct onto PTFE surfaces.

Biomaterials·2005

Same author

Thrombin induces neoangiogenesis in the chick chorioallantoic membrane.

Journal of thrombosis and haemostasis : JTH·2003

Same author

Slow induction of RecA by DNA damage in Mycobacterium tuberculosis.

Microbiology (Reading, England)·2001

Same author

Proteolytic exposure of a cryptic site within collagen type IV is required for angiogenesis and tumor growth in vivo.

The Journal of cell biology·2001

Same author

Identification of some DNA damage-inducible genes of Mycobacterium tuberculosis: apparent lack of correlation with LexA binding.

Journal of bacteriology·2001

Same author

Plasminogen activator inhibitor-1 regulates tumor growth and angiogenesis.

The Journal of biological chemistry·2001

Same journal

Erratum to: Immunotherapeutic Approach to Cancer with Cutaneous DNA Vaccination.

Methods in molecular medicine·2015

Same journal

Methods for cancer gene therapy using tumor suppressor genes.

Methods in molecular medicine·2014

Same journal

Suppression of the human carcinoma phenotype by an antioncogene ribozyme.

Methods in molecular medicine·2014

Same journal

Methods for the use of stromal cells for therapeutic gene therapy.

Methods in molecular medicine·2014

Same journal

Methods for adenovirus-mediated gene transfer to synovium in vivo.

Methods in molecular medicine·2014

Same journal

Methods for gene transfer to synovium.

Methods in molecular medicine·2014

See all related articles

Search research articles

Related Experiment Video

Updated: Jun 4, 2026

Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model

Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model

Published on: May 30, 2011

The chick embryo metastasis model.

E Petitclerc¹, P C Brooks

¹Department of Biochemistry and Molecular Biology, Norris Cancer Center, The University of Southern California School of Medicine, Los Angeles, CA.

Methods in Molecular Medicine

|February 23, 2011

Summary

This summary is machine-generated.

Cancer metastasis, the spread of malignant tumors, remains a major challenge in treatment. Further research is crucial to understand and combat tumor invasion and metastatic dissemination.

More Related Videos

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Published on: February 3, 2021

Related Experiment Videos

Last Updated: Jun 4, 2026

Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model

Quantitative Analysis of Cancer Metastasis using an Avian Embryo Model

Published on: May 30, 2011

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Comparing Metastatic Clear Cell Renal Cell Carcinoma Model Established in Mouse Kidney and on Chicken Chorioallantoic Membrane

Published on: February 8, 2020

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Discovery of Metastatic Regulators using a Rapid and Quantitative Intravital Chick Chorioallantoic Membrane Model

Published on: February 3, 2021

Area of Science:

Oncology
Cancer Biology
Molecular Medicine

Background:

Malignant tumor growth and dissemination significantly impact global health, with hundreds of thousands of new cancer cases diagnosed annually.
Current cancer treatments like surgery, chemotherapy, and radiation have limited success, particularly when tumor cells metastasize.

Purpose of the Study:

To investigate the complex biochemical and molecular mechanisms regulating tumor invasion and metastatic dissemination.
To identify key factors contributing to treatment failure in metastatic cancer cases.

Main Methods:

The study focuses on understanding the molecular mechanisms of tumor invasion.
It examines the biochemical pathways involved in the dissemination of malignant tumor cells.

Main Results:

Significant progress has been made in understanding tumor invasion.
However, much remains to be learned about the intricate molecular mechanisms governing this process.

Conclusions:

Metastatic dissemination of tumor cells is a critical obstacle in cancer treatment.
Further research into the molecular mechanisms of tumor invasion is essential for developing more effective therapies.