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Updated: Jun 4, 2026

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Measurement of Factor V Activity in Human Plasma Using a Microplate Coagulation Assay

Published on: September 9, 2012

Molecular Analysis in Factor XI Deficiency.

K M Johnson¹, J H McVey

¹Haemostasis Research Group, MRC Clinical Sciences Centre, Royal Postgraduate Medical School, Hammersmith Hospital, London, UK.

Methods in Molecular Medicine

|February 23, 2011

Summary

This summary is machine-generated.

Factor XI (FXI) is a protein essential for blood clotting, acting as a precursor to an enzyme involved in the coagulation cascade. It circulates in plasma, forming a complex with high molecular weight kininogen.

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Helical Organization of Blood Coagulation Factor VIII on Lipid Nanotubes

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Published on: June 3, 2014

Area of Science:

Biochemistry
Hematology
Molecular Biology

Background:

Factor XI (FXI) is the zymogen precursor of an active serine protease.
FXI participates in the contact phase of coagulation.
Synthesized in the liver, FXI circulates in plasma.

Purpose of the Study:

To describe the fundamental properties of Factor XI.
To outline its role in the coagulation cascade.
To provide context for further research into FXI function and regulation.

Main Methods:

Literature review of Factor XI.
Analysis of protein structure and function.
Review of coagulation pathway components.

Main Results:

Factor XI circulates in plasma as a homodimeric glycoprotein.
Normal plasma concentration is approximately 5 microg/mL.
It forms a noncovalent complex with high molecular weight kininogen.

Conclusions:

Factor XI is a key component of the intrinsic pathway of coagulation.
Understanding FXI's structure and interactions is crucial for studying hemostasis.
Its concentration and complex formation are important physiological characteristics.