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Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods
08:28

Analysis of Congenital Heart Defects in Mouse Embryos Using Qualitative and Quantitative Histological Methods

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Gastrointestinal system malformations in children are associated with congenital heart defects

Utku Arman Orün1, Meki Bilici, Fulya G Demirçeken

  • 1Clinic of Pediatric Cardiology, Department of Pediatric Cardiology, Faculty of Medicine, Fatih University, Ankara, Turkey.

Anadolu Kardiyoloji Dergisi : AKD = the Anatolian Journal of Cardiology
|February 24, 2011
PubMed

Insights

Congenital heart defects (CHD) affect 28.5% of children with gastrointestinal malformations (GISM). Early cardiac evaluation is crucial for these patients, as mortality rates do not significantly differ between those with and without CHD.

Area of Science:

  • Pediatric Surgery
  • Pediatric Cardiology
  • Medical Genetics

Background:

  • Gastrointestinal malformations (GISM) are a significant concern in pediatric surgery.
  • Congenital heart defects (CHD) are common co-occurring conditions in pediatric patients.
  • Understanding the interplay between GISM and CHD is vital for patient outcomes.

Purpose of the Study:

  • To determine the incidence of congenital heart defects (CHD) in children diagnosed with gastrointestinal malformations (GISM).
  • To investigate the mortality rates associated with GISM, considering the presence or absence of CHD.

Main Methods:

  • Retrospective analysis of 242 pediatric patients with GISM.
  • Cardiovascular anomaly screening by Pediatric Cardiology.
  • Statistical analysis using the Chi-square test.

Main Results:

  • Congenital heart defects (CHD) were identified in 28.5% of pediatric patients with GISM.
  • Atrial septal defect (44.9%), ventricular septal defect (24.6%), and patent ductus arteriosus (7.2%) were the most common CHDs.
  • No significant difference in mortality rates was observed between GISM patients with CHD (16.7%) and without CHD (13.3%).

Conclusions:

  • Early and comprehensive cardiological evaluation is essential for all infants and children diagnosed with gastrointestinal malformations.
  • Proactive cardiac assessment can aid in the management and improve outcomes for pediatric patients with GISM.
Abstract

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