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Updated: Jun 4, 2026
07:24
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
Published on: February 6, 2021
Endogenous methicillin-resistant Staphylococcus aureus endophthalmitis
Vincent Ho1, Lawrence Y Ho, Tushar M Ranchod
1The Ohio State University College of Medicine, Columbus, Ohio, USA.
Retina (Philadelphia, Pa.)
|February 24, 2011
Summary
This study reports on endogenous methicillin-resistant Staphylococcus aureus endophthalmitis, finding retinal detachments common but enucleation rates low. Outcomes show visual acuity improvement in most affected eyes.
Area of Science:
- Ophthalmology
- Infectious Diseases
- Microbiology
Background:
- Endogenous methicillin-resistant Staphylococcus aureus endophthalmitis is a severe intraocular infection.
- Limited data exists on the presentation, treatment, and outcomes of this condition.
Observation:
- A retrospective review of eight eyes from seven patients with culture-proven methicillin-resistant Staphylococcus aureus endophthalmitis.
- The mean age was 58.1 years, with a male predominance (5/7 patients).
- Retinal detachment occurred in six of eight eyes during treatment.
Findings:
- Initial treatment involved vitreous tap and antibiotic injection in five eyes.
- Final visual acuity varied, with 5/8 eyes showing improvement.
- Only one eye required enucleation due to blindness and pain.
Implications:
- This series, the largest single-institution report, suggests better outcomes than previously documented.
- Retinal detachment is a frequent complication, but aggressive management may lead to favorable visual results.
- Findings challenge prior assumptions of universally poor outcomes and high enucleation rates for this infection.
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