Related Experiment Video
Updated: Jun 4, 2026
Intrathecal Application of a Fluorescent Dye for the Identification of Cerebrospinal Fluid Leaks in Cochlear Malformation
Published on: February 29, 2020
Skew deviation after intratympanic gentamicin therapy
Diana Ng1, Mohammad Fouladvand, Anil K Lalwani
1Department of Ophthalmology, New York University School of Medicine, New York, New York, USA.
Abstract:
Intratympanic gentamicin therapy for the treatment of episodic vertigo associated with Ménière's disease is generally well tolerated. Although auditory and vestibular symptoms following intratympanic gentamicin are well known, visual disturbance has not been previously described. In this report, we describe two patients with Ménière's disease who developed sudden onset of binocular vertical diplopia due to skew deviation after intratympanic gentamicin therapy. The skew deviation and diplopia resolved spontaneously and completely within 6 to 8 weeks without therapy. Development of diplopia due to skew deviation should be discussed as a potential complication in patients undergoing intratympanic gentamicin therapy.
Insights
Intratympanic gentamicin for Ménière's disease can cause temporary double vision. This visual disturbance, specifically skew deviation, resolved on its own in two patients within weeks.
Area of Science:
- Otolaryngology
- Neurology
- Ophthalmology
Background:
- Intratympanic gentamicin is a common treatment for Ménière's disease, primarily targeting vertigo.
- Auditory and vestibular side effects are known, but visual disturbances are not well-documented.
Purpose of the Study:
- To report a previously undescribed visual complication of intratympanic gentamicin therapy.
- To highlight the potential for skew deviation and diplopia following this treatment.
Main Methods:
- Case report of two patients with Ménière's disease.
- Observation of visual symptoms after receiving intratympanic gentamicin injections.
Main Results:
- Both patients developed sudden onset binocular vertical diplopia.
- The diplopia was attributed to skew deviation.
- Symptoms resolved spontaneously within 6 to 8 weeks without intervention.
Conclusions:
- Sudden onset diplopia due to skew deviation is a potential, albeit rare, complication of intratympanic gentamicin.
- This visual disturbance can resolve spontaneously.
- Clinicians should counsel patients on this possible side effect.
More Related Videos
06:55A Surgical Procedure for the Administration of Drugs to the Inner Ear in a Non-Human Primate Common Marmoset (Callithrix jacchus)
Published on: February 27, 2018
09:18A Comparative Study of Drug Delivery Methods Targeted to the Mouse Inner Ear: Bullostomy Versus Transtympanic Injection
Published on: March 8, 2017
