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Related Concept Videos

Protein Networks02:26

Protein Networks

An organism can have thousands of different proteins, and these proteins must cooperate to ensure the health of an organism. Proteins bind to other proteins and form complexes to carry out their functions. Many proteins interact with multiple other proteins creating a complex network of protein interactions.
These interactions can be represented through maps depicting protein-protein interaction networks, represented as nodes and edges. Nodes are circles that are representative of a protein,...
Proteomics01:33

Proteomics

A proteome is the entire set of proteins that a cell type produces. We can study proteomes using the knowledge of genomes because genes code for mRNAs, and the mRNAs encode proteins. Although mRNA analysis is a step in the right direction, not all mRNAs are translated into proteins.
Proteomics is the study of proteomes' function. It involves the large-scale systematic study of the proteome to denote the protein complement expressed by a genome. Scientist Mark Wilkins coined the term proteomics...
The Proteasome Structure01:17

The Proteasome Structure

The ubiquitin-proteasome pathway is a well-known mechanism utilized by eukaryotic cells to remove cytoplasmic proteins that are misfolded, damaged, or no longer needed. In this pathway, the protein that needs to be eliminated undergoes a process called ubiquitination, where a chain of ubiquitin molecules is attached to the 48th lysine residue of the target protein. This ubiquitin modification helps the proteasome distinguish between a target protein and a healthy protein.
The proteasome is an...
Protein-Protein Interfaces02:04

Protein-Protein Interfaces

Many proteins form complexes to carry out their functions, making protein-protein interactions (PPIs) essential for an organism's survival. Most PPIs are stabilized by numerous weak noncovalent chemical forces. The physical shape of the interfaces determines the way two proteins interact. Many globular proteins have closely-matching shapes on their surfaces, which form a large number of weak bonds. Additionally, many PPIs occur between two helices or between a surface cleft and a polypeptide...
Protein and Protein Structures02:15

Protein and Protein Structures

Proteins are one of the most abundant organic molecules in living systems and have the most diverse range of functions of all macromolecules. Proteins may be structural, regulatory, contractile, or protective. They may serve in transport, storage, or membranes; or they may be toxins or enzymes. Their structures, like their functions, vary greatly. They are all, however, amino acid polymers arranged in a linear sequence.
A protein's shape is critical to its function. For example, an enzyme can...
ATP Yield01:31

ATP Yield

Cellular respiration produces 30 - 32 ATP per glucose molecule. Although most of the ATP results from oxidative phosphorylation and the electron transport chain (ETC), 4 ATP are gained beforehand (2 from glycolysis and 2 from the citric acid cycle).
The ETC is embedded in the inner mitochondrial membrane and is comprised of four main protein complexes and an ATP synthase. NADH and FADH2 pass electrons to these complexes, which pump protons into the intermembrane space. This distribution of...

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Related Experiment Video

Updated: Jun 4, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

Literature Mapping with PubAtlas - extending PubMed with a 'BLASTing interface'.

D S Parker1, W W Chu, F W Sabb

  • 1Computer Science Dept, UCLA;

Summit on Translational Bioinformatics
|February 25, 2011
PubMed
Summary

PubAtlas offers a novel web service for creating interactive literature maps from biomedical research. This tool enhances PubMed by enabling detailed analysis of term associations and historical trends in scientific publications.

Related Experiment Videos

Last Updated: Jun 4, 2026

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases
05:02

Comparing Bibliometric Analysis Using PubMed, Scopus, and Web of Science Databases

Published on: October 24, 2019

Area of Science:

  • Biomedical Informatics
  • Bibliometrics
  • Scientific Literature Analysis

Background:

  • Biomedical research generates vast amounts of literature, making comprehensive analysis challenging.
  • Existing tools offer limited capabilities for exploring relationships between research terms.
  • There is a need for advanced platforms to visualize and analyze scientific literature effectively.

Purpose of the Study:

  • To introduce PubAtlas, a web service and standalone program for generating literature maps.
  • To extend PubMed's functionality with an interactive literature analysis interface.
  • To provide tools for exploring term associations and historical trends in biomedical literature.

Main Methods:

  • PubAtlas accepts user-defined sets of terms (PubMed queries) as input.
  • It performs pairwise intersections (x AND y) between term sets using an 'all vs. all' approach.
  • Literature maps are presented as interactive tabular displays in a heatmap/microarray format.

Main Results:

  • PubAtlas enables the exploration of associations among sets of terms through interactive literature maps.
  • The platform supports the development of specialized lexica and user-defined query languages.
  • Temporal query features provide historical perspectives on research patterns.

Conclusions:

  • PubAtlas serves as a framework for extending the PubMed interface.
  • It offers an extensible platform for creating interactive visualizations of biomedical literature.
  • The tool facilitates deeper understanding of research landscapes and trends.