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Multiple sclerosis is a chronic autoimmune disease of the central nervous system (CNS) that affects the brain, spinal cord, and optic nerves. It is an inflammatory demyelinating disorder and a leading cause of neurological disability in young adults.EpidemiologyMS commonly begins between 20 and 40 years of age and is twice as common in women. Its exact cause remains unclear, but genetic susceptibility contributes, with higher risk in first-degree relatives and identical twins. A greater...
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Related Experiment Video

Updated: Jun 4, 2026

Dynamic Visual Tests to Identify and Quantify Visual Damage and Repair Following Demyelination in Optic Neuritis Patients
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Supratentorial multiple sclerosis lesions affect the blink reflex test.

Efthimios H Mikropoulos1, Afroditi A Papathanasiou, Georgios Hadjigeorgiou

  • 1Department of Neurology, Faculty of Medicine, School of Health Sciences, University of Thessaly, P.O. Box 1400, Mezourlo Hill, Larissa, Greece.

The Open Neurology Journal
|February 25, 2011
PubMed
Summary

The Blink Reflex Test (BRT) effectively assesses neurological function in Multiple Sclerosis (MS) patients. Brainstem lesions do not significantly impact BRT sensitivity, suggesting supratentorial lesions play a key role.

Keywords:
Blink Reflex TestBrainstem.MRI BrainMultiple SclerosisSupratentorial Lesions

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Area of Science:

  • Neurophysiology
  • Neuroimaging
  • Neurology

Background:

  • The Blink Reflex Test (BRT) evaluates brainstem reflex circuits.
  • Magnetic Resonance Imaging (MRI) precisely visualizes Multiple Sclerosis (MS) lesion anatomy.
  • Understanding the correlation between BRT function and MS lesion location is crucial.

Purpose of the Study:

  • To investigate the relationship between functional BRT results and the anatomical location of MS lesions detected via routine MRI.
  • To determine if MS lesion location influences the diagnostic sensitivity of the BRT.

Main Methods:

  • 65 patients diagnosed with MS were included in the study.
  • Patients underwent the BRT within two months of a brain MRI scan.
  • MRI scans identified demyelinating lesions characteristic of MS.

Main Results:

  • The BRT demonstrated an overall sensitivity of 90.8% in detecting neurological abnormalities.
  • Sensitivity was high (91.4%) in patients with brainstem lesions and slightly lower (90%) in those without.
  • These findings indicate that brainstem lesion presence did not significantly alter BRT sensitivity.

Conclusions:

  • The study suggests that supratentorial MS lesions, rather than brainstem lesions, significantly influence BRT outcomes.
  • BRT sensitivity is not significantly affected by the presence or absence of brainstem lesions.
  • Factors like gender, age, disease duration, MS type, and diagnosis recency did not impact BRT results.