Related Experiment Video
Updated: Jun 4, 2026

Rapid Point-of-Care Assay of Enoxaparin Anticoagulant Efficacy in Whole Blood
Published on: October 12, 2012
[Oral cavity delivery system of unfractionated and low molecular weight heparin]
1National Pharmaceutical Engineering & Research Center Shanghai 201203, China.
Abstract:
The difference between absorption of unfractionated heparin (UFH) and low molecular weight heparin (LMWH) after oral and oral cavity administration were studied respectively, and the compatible enhancer for oral cavity delivery system of both drugs was found. The LMWH and UFH films were prepared with two bioadhesive materials Carbopol and alginate sodium for oral cavity delivery. The activated partial thromboplastin time (APTT) was used to determine LMWH and UFH in plasma after oral, oral cavity and sc administration in rats. The results show that the enhancer (Labrasol) can increase the absorption of LMWH and UFH through oral cavity in rats but not obviously. The oral cavity iontophoretic delivery system is a useful method to improve the absorption of LMWH and UFH through oral cavity mucosa.
Related Concept Videos
Anticoagulant Drugs: Low-Molecular-Weight Heparins
Parenteral Drug Delivery Systems: Injectables, Implants, and Infusion Devices
Oral Drug Delivery Systems: Continuous-Release Systems
Venous Thrombosis III: Interprofessional Care
Routes of Drug Administration: Parenteral
The intravenous route (IV) of drug administration can be further categorized into two types. The bolus injection administers the entire dose rapidly, while an intravenous infusion slowly delivers smaller doses steadily.
The IV route is often...
Oral Drug Delivery Systems: Introduction

