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It's hard to keep all things angiogenic in one JAR!

Jan Kitajewski1, Yihai Cao, Mark Slevin

  • 1Columbia University Medical Centre, Columbia New York, USA. jkk9@columbia.edu.

Vascular Cell
|February 26, 2011
PubMed
Summary

No abstract available in PubMed .

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Blood vessel formation starts early during embryonic development, around day 7. In the extraembryonic yolk sac, mesodermal precursor cells called hemangioblast proliferate and differentiate into angioblast. Angioblasts express vascular endothelial growth factor receptor 2 or VEGFR2, which binds VEGF-A, a proangiogenic factor, guiding blood vessel formation. VEGF signaling promotes angioblasts to form a blood island in the developing embryo. Angioblasts further differentiate, giving rise to...

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