[Studies on bone and suppurative lesion distribution of antimicrobial suppositories (Ampicillin and Ceftizoxime) to...

The investigation has been made regarding transfer of the antimicrobial agents into the osseous tissues in rabbit and into the mandibula in experimental infected rabbit model by making intrarectal administration of ampicillin (ABPC) and ceftizoxime (CZX). The preparation of the infected model were made according to the procedure of Satoh and Heimdahl. Pharmacokinetic analysis was made by measuring concentration of these antimicrobial suppositories transferred according to the biological measuring method in serum, mandibula, maxilla, ilium, tibia, sternum, liver and pus. The results were as follows: 1) In the infected group given ABPC, the concentration of the drug in mandibula and maxilla were approx. 21.5-52.9% of those in serum. 2) In the normal healthy group given ABPC, their concentration in tissues were approx. 13.9-23.7% of those in serum. 3) In the infected group given CZX, their concentration in pus and osseous tissues were approx. 12.7-61.8%. 4) In the normal healthy group given CZX, their concentration in osseous tissues were approx. 12.4-22.9% of those in serum. 5) In a comparison made between the infected and normal healthy group, transfer of the drugs into the infected group were observed in higher rates in serum and all osseous tissues. 6) The serum concentration of the antimicrobial suppositories (ABPC and CZX) by intrarectal administration showed transfer in far higher rate than those by oral administration and exhibited transfer of concentration at its peak equal to that by intramuscular administration.