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Updated: Jun 4, 2026

A Multicenter MRI Protocol for the Evaluation and Quantification of Deep Vein Thrombosis
Published on: June 2, 2015
Magnetic resonance VIBE venography using the blood pool contrast agent gadofosveset trisodium--an interrater
Alexander Pfeil1, Stefan Betge, Guenther Poehlmann
1Department of Internal Medicine III, Friedrich-Schiller-University Jena, Erlanger Allee 101, 07747 Jena, Germany.
Purpose:
In this study, image quality of leg veins and vena cava inferior was scored by independent raters using the new intravascular magnetic resonance imaging (MRI) contrast agent gadofosveset trisodium using fat-suppressed 3D gradient echo Volume Interpolated Breath-hold Examination.
Material And Methods:
The leg venous system without clinical signs of deep venous thrombosis (DVT) and sonography-ruled out DVT were imaged using a fat-suppressed 3D gradient echo Volume Interpolated Breath-hold Examination (VIBE FS). Image interpretation was done independently by two experienced radiologists (raters) using a 5-point scoring system.
Results:
High diagnostic image quality with an overall mean visibility score of 4.8±0.1 was acquired in patients enrolled in the study using gadofosveset trisodium-enhanced MRI for the venous system of the leg. There were no cases with moderate, poor or nondiagnostic image quality. Additionally, an excellent interrater reliability was observed.
Conclusions:
This study shows the feasibility of acquiring high resolution images with excellent image quality of the venous system of the leg using gadofosveset trisodium.
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