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Related Concept Videos

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions01:27

Nondepolarizing (Competitive) Neuromuscular Blockers: Pharmacological Actions

Nondepolarizing neuromuscular blockers prevent the membrane depolarization of muscle cells and inhibit muscle contraction. These are usually administered with anesthetics to achieve complete muscle relaxation. Upon administration, these drugs first block the small, rapidly contracting muscles of the face and hands, followed by the larger muscles of the trunk and the intercostal muscles. The diaphragm is the last muscle to be affected.
Although all competitive neuromuscular blockers are designed...
Depolarizing Blockers: Mechanism of Action01:28

Depolarizing Blockers: Mechanism of Action

Depolarizing blockers act on skeletal muscle fibers' membranes and induce their depolarization. Most depolarizing blockers have two quaternary N+ atoms that bind the nicotinic acetylcholine receptors and cause neuromuscular blockade within minutes.
Succinylcholine is the most commonly used depolarizing blocker. Chemically, it constitutes two molecules of acetylcholine joined together by an acetate methyl group. They act on the receptors in the same way as acetylcholine. Because succinylcholine...
Local Anesthetics: Clinical Application as Spinal Anesthesia01:11

Local Anesthetics: Clinical Application as Spinal Anesthesia

Spinal anesthetics are given during lower abdomen and limb surgeries to block sensory and motor neurons. They are administered in the mid to low lumbar regions, primarily acting on the cauda equina's nerve roots. The blockade level depends on the local anesthetic (LA) concentration. Usually, low LA concentrations are sufficient to block sensory fibers, while only high LA concentrations block motor fibers. Other factors like injection volume and speed, the patient's posture, and the drug...
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia01:16

Local Anesthetics: Clinical Application as Intravenous Regional Anesthesia

Intravenous regional anesthesia or the Bier block technique is used to anesthetize a specific limb or extremity. It uses exsanguinated or blood-drained vessels to transport local anesthetics or LAs to the peripheral nerve trunks. Lidocaine without vasoconstrictors like epinephrine is most commonly used for this technique. Other drugs used are prilocaine, ropivacaine, and chloroprocaine. Bupivacaine is not recommended for this technique due to its high cardiac toxicity.
One of the advantages of...

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Non-Intubated Video-Assisted Thoracoscopic Surgery
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Paravertebral-peridural block technique: a unilateral thoracic block.

R Tenicela1, S B Pollan

  • 1Pain Control Center, Presbyterian-University Hospital, Pittsburgh, Pennsylvania.

The Clinical Journal of Pain
|September 1, 1990
PubMed
Summary

The paravertebral-peridural block offers a safe and effective method for unilateral thoracic anesthesia across multiple dermatomes. This technique provides reliable pain relief with a low complication rate, benefiting patients with acute and chronic pain.

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Area of Science:

  • Anesthesiology
  • Pain Management
  • Thoracic Surgery

Background:

  • Achieving unilateral anesthesia in multiple thoracic dermatomes is crucial for pain management.
  • The multidermatomal intercostal technique's mechanism is debated.
  • A modified paravertebral block, termed paravertebral-peridural block, has been utilized for over two decades.

Purpose of the Study:

  • To evaluate the safety and efficacy of the paravertebral-peridural block for unilateral anesthesia.
  • To clarify the anatomical mechanism behind potential bilateral blockade from this unilateral technique.

Main Methods:

  • Retrospective analysis of 384 paravertebral-peridural blocks performed between 1982 and 1986.
  • Cadaveric injection study using colored latex to visualize spread after paravertebral-peridural approach.

Main Results:

  • Low complication rates: 0.26% pneumothorax, 0.26% thecal puncture, 0.52% intrathecal injection, 4.6% transient hypotension.
  • 93% of blocks were rated "good" or "excellent".
  • Cadaver study revealed prevertebral midline spread to the contralateral paravertebral space, explaining bilateral blockade.

Conclusions:

  • The paravertebral-peridural thoracic block is a reliable and safe technique.
  • It effectively achieves unilateral anesthesia over multiple dermatomes with a single injection.
  • Understanding the anatomical spread clarifies the mechanism of action.