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Updated: Jun 4, 2026

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells
08:00

Derivation of Cardiac Progenitor Cells from Embryonic Stem Cells

Published on: January 12, 2015

Cardiac progenitor cell commitment is inhibited by nuclear Akt expression.

Kimberlee M Fischer1, Shabana Din, Natalie Gude

  • 1San Diego State Heart Institute, San Diego State University, CA, USA.

Circulation Research
|February 26, 2011
PubMed
Summary

Genetically modified cardiac progenitor cells (CPCs) overexpressing Akt showed increased proliferation but failed to improve heart function due to impaired lineage commitment. Akt inhibition restored lineage commitment, suggesting inducible systems may enhance stem cell therapy for heart disease.

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