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Related Experiment Video

Updated: Jun 4, 2026

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study
06:58

A Structured Rehabilitation Protocol for Improved Multifunctional Prosthetic Control: A Case Study

Published on: November 6, 2015

Prosthesis-patient mismatch: an update.

Jean G Dumesnil1, Philippe Pibarot

  • 1Quebec Heart and Lung Institute, 2725 Chemin Sainte-Foy, Québec, Quebec, Canada G1V-4G5. jean.dumesnil@med.ulaval.ca

Current Cardiology Reports
|February 26, 2011
PubMed
Summary
This summary is machine-generated.

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Prosthesis-patient mismatch (PPM) occurs when a prosthetic valve is too small, leading to higher gradients and poorer outcomes. This review updates knowledge on diagnosing, prognosing, and preventing PPM, which is largely preventable with a proactive surgical approach.

Area of Science:

  • Cardiology
  • Cardiac Surgery
  • Biomedical Engineering

Background:

  • Prosthesis-patient mismatch (PPM) is a common complication after aortic valve replacement.
  • It is defined by an inadequate effective orifice area of the prosthetic valve relative to patient body size.
  • PPM leads to higher transvalvular gradients despite normal valve function.

Purpose of the Study:

  • To provide an updated review on the diagnosis of PPM.
  • To summarize the prognostic implications of PPM.
  • To discuss strategies for the prevention of PPM.

Main Methods:

  • Literature review of studies on prosthesis-patient mismatch.
  • Analysis of hemodynamic consequences and clinical outcomes associated with PPM.
  • Evaluation of diagnostic criteria and prognostic factors.

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Last Updated: Jun 4, 2026

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Main Results:

  • PPM occurs in 20% to 70% of aortic valve replacements.
  • PPM is linked to adverse hemodynamics, reduced left ventricular hypertrophy regression, increased cardiac events, and lower survival rates.
  • A prospective strategy during surgery can largely prevent PPM.

Conclusions:

  • PPM is a significant clinical issue with substantial negative impacts on patient outcomes.
  • Early diagnosis and prevention are crucial for improving results after aortic valve replacement.
  • Proactive surgical planning offers a viable strategy to mitigate PPM.