Related Experiment Video
Updated: Jun 4, 2026
11:13
A GPC3-targeting Bispecific Antibody, GPC3-S-Fab, with Potent Cytotoxicity
Published on: July 12, 2018
[G3BP: a promising target for cancer therapy]
1Institute of Medicinal Biotechnology, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China.
Yao Xue Xue Bao = Acta Pharmaceutica Sinica
|March 1, 2011
Summary
Ras-GTPase-activating protein SH3 domain binding protein (G3BP) is an RNA-binding protein involved in cell signaling and RNA metabolism. Its overexpression in cancers suggests G3BP as a potential therapeutic target for cancer treatment.
Area of Science:
- Molecular Biology
- Cancer Biology
- Biochemistry
Background:
- Ras-GTPase-activating protein SH3 domain binding protein (G3BP) is an RNA-binding protein.
- G3BP is implicated in Ras signaling pathways, RNA metabolism, and stress granule formation.
- Overexpression of G3BP is observed in various human malignancies.
Purpose of the Study:
- To investigate the role of G3BP in cancer biology.
- To evaluate G3BP as a potential therapeutic target for cancer therapy.
Main Methods:
- Literature review and analysis of G3BP's known functions and involvement in cancer pathways.
- Examination of G3BP's association with tumor invasion and metastasis.
Main Results:
- G3BP exhibits endoribonuclease and DNA helicase activities.
- G3BP influences cell proliferation, differentiation, apoptosis, and RNA metabolism.
- G3BP overexpression correlates with tumor invasion and metastasis.
Conclusions:
- G3BP plays a significant role in cellular processes relevant to cancer development.
- G3BP represents a promising novel target for developing new cancer therapies.
Related Concept Videos
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:57Targeted Cancer Therapies
The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
There are several types of targeted therapies against specific...
02:38Mitogens and the Cell Cycle
Mitogens and their receptors play a crucial role in controlling the progression of the cell cycle. However, the loss of mitogenic control over cell division leads to tumor formation. Therefore, mitogens and mitogen receptors play an important role in cancer research. For instance, the epidermal growth factor (EGF) - a type of mitogen and its transmembrane receptor (EGFR), decides the fate of the cell's proliferation. When EGF binds to EGFR, a member of the ErbB family of tyrosine kinase...