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Related Experiment Video

Updated: Jun 4, 2026

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence

Published on: October 11, 2018

Bacteriological aspects implicated in abdominal surgical emergencies.

A M Israil¹, C Delcaru, R S Palade

¹Cantacuzino Institute, Bucharest. ancaisrail@yahoo.com

Chirurgia (Bucharest, Romania : 1990)

|March 1, 2011

Summary

This summary is machine-generated.

This study identified the microbial causes of abdominal surgical emergencies, finding that endogenous bacteria produce virulence factors contributing to disease severity. Results suggest revising empiric antibiotic therapies for better patient outcomes.

Related Experiment Videos

Last Updated: Jun 4, 2026

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence

A Ligated Intestinal Loop Model in Anesthetized Specific Pathogen Free Chickens to Study Clostridium Perfringens Virulence

Published on: October 11, 2018

Area of Science:

Microbiology
Surgical Infections
Bacterial Pathogenesis

Background:

Abdominal surgical emergencies present complex microbial challenges.
Understanding bacterial etiology and virulence is crucial for effective treatment.

Purpose of the Study:

To determine the microbial etiology of abdominal surgical emergencies.
To investigate the relationship between bacterial strains and their virulence factors.

Main Methods:

Isolated and identified 110 bacterial strains from 100 clinical cases.
Characterized strains using cultural, microscopic, and biochemical methods.
Assessed bacterial virulence potential, including adherence and soluble factor production.

Main Results:

Enterobacteriaceae and anaerobic bacteria (Clostridium, Peptococcus, Bacteroides) were dominant etiologies.
Commensal bacteria like Bifidobacterium and Veillonella were implicated in severe cases.
All isolated strains exhibited virulence factors (mucinase, toxins, adherence), correlating with clinical severity.

Conclusions:

The bacterial etiology of abdominal surgical emergencies is diverse, with a high prevalence of endogenous strains.
Isolated bacteria possess significant virulence factors, contributing to the severity and diversity of clinical presentations.
Findings support the need for periodic re-evaluation of empiric antibiotic therapy protocols.