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Blood tests and histological correlates in children with eosinophilic oesophagitis

M Marlais1, N D Francis, J M E Fell

  • 1Department of Paediatric Gastroenterology, Chelsea and Westminster Hospital, and Department of Histopathology, Imperial College Healthcare NHS Trust, London, UK. mm1305@ic.ac.uk

Acta Paediatrica (Oslo, Norway : 1992)
|March 1, 2011
PubMed

Insights

Blood tests, including eosinophil counts and immunoglobulin E levels, often show abnormalities in children diagnosed with Eosinophilic Esophagitis (EoE). These blood markers correlate with esophageal histology findings in pediatric EoE patients.

Area of Science:

  • Pediatric Gastroenterology
  • Allergy and Immunology
  • Otolaryngology

Background:

  • Eosinophilic Esophagitis (EoE) is a chronic immune-mediated esophageal disease.
  • Accurate diagnosis of EoE relies on esophageal biopsies showing eosinophilic infiltration.
  • Non-invasive diagnostic markers are needed to complement histological findings.

Purpose of the Study:

  • To investigate the relationship between peripheral blood test results and esophageal histology in children diagnosed with EoE.
  • To assess the utility of blood eosinophil count, serum total IgE, and RAST tests in pediatric EoE.

Main Methods:

  • Retrospective analysis of 40 children diagnosed with EoE between 2000-2009.
  • Evaluation of blood eosinophil count, serum total IgE, and RAST results for common food allergens.
  • Prospective re-review of esophageal histology to determine mean eosinophil counts.
  • Correlation analysis using Spearman's rank test.

Main Results:

  • At diagnosis, 78% of children had elevated blood eosinophil counts, 90% had high serum total IgE, and 83% had positive RAST tests.
  • Significant correlations were found between mean esophageal eosinophil counts and both blood eosinophil count (p=0.008) and serum total IgE (p=0.008).
  • The study included children aged 0-15 years, with a median age of 6.5 years at diagnosis.

Conclusions:

  • Blood tests frequently exhibit abnormalities at the time of EoE diagnosis in children.
  • The findings demonstrate a significant association between esophageal histological findings and blood test results in pediatric EoE.
  • Peripheral blood markers may serve as useful indicators in the diagnostic workup of EoE.
Abstract

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