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Updated: Jun 4, 2026

A Protocol for Computer-Based Protein Structure and Function Prediction
Published on: November 3, 2011
Protein function prediction: towards integration of similarity metrics
Serkan Erdin1, Andreas Martin Lisewski, Olivier Lichtarge
1Department of Molecular and Human Genetics, 1 Baylor Plaza, Baylor College of Medicine, Houston, TX 77030, USA.
None:
Genomic centers discover increasingly many protein sequences and structures, but not necessarily their full biological functions. Thus, currently, less than one percent of proteins have experimentally verified biochemical activities. To fill this gap, function prediction algorithms apply metrics of similarity between proteins on the premise that those sufficiently alike in sequence, or structure, will perform identical functions. Although high sensitivity is elusive, network analyses that integrate these metrics together hold the promise of rapid gains in function prediction specificity.
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