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8-Hydroxynaphthalene-1,4-dione derivative as novel compound for glioma treatment
Giuseppe Zagotto1, Marco Redaelli, Riccardo Pasquale
1Department of Pharmaceutical Sciences, University of Padova, Padova, Italy. giuseppe.zagotto@unipd.it
Bioorganic & Medicinal Chemistry Letters
|March 1, 2011
Abstract:
Malignant gliomas continue to demand the search for improved chemotherapeutic solutions. In this work the results of a preliminary in vitro screening performed on a small library of compounds are disclosed. As a result 2-(2,4-dihydroxyphenyl)-8-hydroxy-1,4-naphthoquinone emerged as a promising therapeutic lead.
