Related Experiment Video
Updated: Jun 4, 2026
10:56
Neural Stem Cell Transplantation in Experimental Contusive Model of Spinal Cord Injury
Published on: December 17, 2014
Current research outcomes from the spinal cord injury model systems
Yuying Chen1, Anne Deutsch, Michael J DeVivo
1Department of Physical Medicine and Rehabilitation, University of Alabama at Birmingham, Birmingham, AL, USA. yychen@uab.edu
Archives of Physical Medicine and Rehabilitation
|March 1, 2011
Summary
The Spinal Cord Injury Model Systems program advances research to improve health and quality of life for individuals with spinal cord injury (SCI). This issue highlights diverse SCIMS findings, from epidemiology to assistive technology.
Area of Science:
- Rehabilitation Medicine
- Disability Research
- Spinal Cord Injury Research
Background:
- The Spinal Cord Injury Model Systems (SCIMS) program, established in 1970, aims to improve care and outcomes for individuals with spinal cord injury (SCI).
- SCIMS research has been disseminated through various publications and dedicated journal issues over the past decades.
- This special issue presents a comprehensive collection of 24 articles showcasing current SCIMS research.
Related Concept Videos
01:14Spinal Cord Injury ll: Pathophysiology
Spinal cord injury progresses through two interconnected phases: primary injury and secondary injury.Primary InjuryPrimary injury happens at the moment of trauma and involves immediate mechanical damage to the spinal cord.Compression happens when broken vertebrae, herniated discs, or accumulating blood (such as a hematoma) press directly against the spinal cord, distorting its normal shape and function. In cases of contusion, the cord is bruised by a blunt force (like penetrating injuries or...
01:25Secondary Spinal Cord Injury llI: Pathophysiology
Early Ischemia and Ionic ImbalanceWithin minutes of spinal cord injury, a secondary cascade begins, progressing over hours to weeks. Vascular damage reduces blood flow, causing ischemia and mitochondrial dysfunction. ATP depletion leads to ion pump failure, membrane depolarization, sodium influx, potassium efflux, and water accumulation, resulting in cellular swelling. Increased intracellular calcium further disrupts mitochondria and accelerates cellular injury.Excitotoxicity and Neuronal...