Coumarin metabolic routes in Aspergillus spp
Celeste Aguirre-Pranzoni1, Alejandro A Orden, Fabricio R Bisogno
1INTEQUI-CONICET, Facultad de Química, Bioquímica y Farmacia, Universidad Nacional de San Luis, Chacabuco y Pedernera, San Luis, Argentina.
Abstract:
Coumarin metabolism by several Aspergillus strains was studied. Aspergillus ochraceus and Aspergillus niger carried out the reduction of the C3-C4 double bond to yield dihydrocoumarin in 24h. Meanwhile, the first strain did not transform dihydrocoumarin after 7d, A. niger demonstrated to have two divergent catabolic pathways: (a) the lactone moiety opening and further reduction of the carboxylic acid furnishing the primary alcohol 2-(3-hydroxypropyl)phenol and, (b) the hydroxylation of the aromatic ring of dihydrocoumarin at a specific position to give 6-hydroxy-3,4-dihydrochromen-2-one. Aspergillus flavus did not perform double bond reductions, and only produced oxygenated metabolites, mainly 5-hydroxycoumarin. Enzyme-specific inhibitors and a coumarin analogous were useful to confirm the A. niger catabolic route.
More Related Videos
Related Concept Videos
Amino Acid Biosynthetic Pathways
Drug Excretion: Miscellaneous Routes
Drug Elimination: Non-Renal Routes
Fungal Phylum Ascomycota
Antifungal Agents
C4 Pathway and CAM
C4 Pathway
The C4 pathway is used by plants such as...


