[Preparation of Ginkgo biloba extract 50-phospholipid complex and study on its physicochemical properties]
Le Lai1, Chun-Li Lai, Jian-Bin Zhao
1NanFang Hospital, Southern Medicine University, Guangzhou 510515, China. laile1986@163.com
Objective:
To optimize the preparation technology of GBE 50-phospholipid complex and study its physicochemical properties.
Methods:
The preparation conditions for GBE 50-phospholipid complex were optimized by means of single factor study and orthogonal design, and taking the complexing rate of total flavonoids as assessment criteria, the complex was analyzed by DSC, IR and determined apparent oil-water distribution coefficients in different pH aqueous solution.
Results:
The optimized preparation conditions for GBE 50-phospholipid complex were obtained as follows: the solvent was Tetrahydrofuran, the temperature was 30 degrees C, the concentration of GBE 50 was 20 mg/mL, the ratio of GBE 50 to phospholipids was 1 to 1, and the complexing rate was 98%. The complex significantly improved GBE 50 on the solubility in octanol, also on the oil-water apparent partition coefficient.
Conclusion:
GBE 50-phospholipid complex is very different from GBE 50 on the physicochemical properties.
