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Updated: Jun 4, 2026
06:01
Using An In Vitro Tissue Perfusion System to Detect the Functional Activities of Isolated Intestinal Tubes in Real Time
Published on: July 26, 2024
[Study on novel colon position pulsatile capsule and its release in vitro]
Jing Liu1, Liangke Zhang, Chengyuan Wang
1School of Pharmacy, Chongqing Medical University, Chongqing 400016, China.
Summary
This study developed a colon-targeted pulsatile capsule drug delivery system using a konjac glucomannan plug tablet to control drug release. Adjusting the plug tablet
Area of Science:
- Pharmaceutical Sciences
- Drug Delivery Systems
Background:
- Colon drug delivery systems aim for targeted release in the large intestine.
- Pulsatile drug release systems offer controlled lag-time before drug delivery.
Purpose of the Study:
- To develop a colon-specific pulsatile capsule drug delivery system.
- To control the lag-time using a plug tablet primarily composed of konjac glucomannan.
- To evaluate the in vitro drug release profile of the developed system.
Main Methods:
- Impermeable capsule bodies were prepared via a filling method.
- Plug tablets were fabricated using direct compression.
- Rapidly disintegrating drug tablets were produced through wet granulation.
- Pulsatile capsules were assembled by inserting drug tablets into capsule bodies and sealing with plug tablets.
- Lag-time factors were analyzed using in vitro dissolution testing.
Main Results:
- The formulation of rapidly disintegrating drug tablets impacted pulsatile drug release.
- The plug tablet's composition significantly influenced the lag-time.
- Increased konjac glucomannan proportion and higher hydroxypropyl methylcellulose (HPMC) viscosity extended the lag-time.
Conclusions:
- A pulsatile capsule with appropriate lag-time for colon targeting is achievable.
- The composition of the plug tablet is key to controlling lag-time and colon-specific delivery.
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