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Opossum (Monodelphis domestica): A Marsupial Development Model
Anna L Keyte1, Kathleen K Smith
1Department of Biology, Duke University, Durham, NC 27708, USA.
CSH Protocols
|March 2, 2011
Summary
The South American grey short-tailed opossum (Monodelphis domestica) is a valuable laboratory marsupial due to its convenient characteristics and sequenced genome. This article provides an overview of its biology and use as a model organism.
Area of Science:
- Comparative biology
- Developmental biology
- Genomics
Background:
- Monodelphis domestica is the most widely utilized laboratory marsupial.
- Its convenience as a lab animal is enhanced by its small size, ease of care, and nonseasonal breeding.
- It is the first marsupial species with a fully sequenced genome.
Purpose of the Study:
- To provide a comprehensive overview of Monodelphis domestica biology.
- To highlight its utility as a model organism in scientific research.
- To discuss practical aspects of its care, breeding, and use in developmental studies.
Main Methods:
- Review of existing literature on Monodelphis domestica.
- Compilation of information on husbandry and breeding protocols.
- Description of techniques for embryo manipulation.
- Adaptation of common laboratory methods for this species.
Main Results:
- Monodelphis domestica offers a unique combination of practical advantages for laboratory use.
- The availability of its genome sequence facilitates advanced research.
- Specific methods for its care and experimental manipulation are detailed.
Conclusions:
- Monodelphis domestica is an exceptionally useful marsupial model organism.
- Its biological features and genomic resources support diverse research applications.
- The article serves as a guide for researchers utilizing this species.
