Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
The Retinoblastoma Gene01:20

The Retinoblastoma Gene

Tumor suppressor genes are normal genes that can slow down cell division, repair DNA mistakes, or program the cells for apoptosis in case of irreparable damage. Hence, they play an essential role in preventing the proliferation of damaged cells.
The first-ever tumor suppressor gene called Rb was identified in retinoblastoma - a rare eye tumor in children. In inherited forms of the disease, a child inherits one defective copy of the Rb gene, which predisposes them to retinoblastoma. However,...
Sympathetic Pathways: Sympathetic Chain Ganglia01:20

Sympathetic Pathways: Sympathetic Chain Ganglia

The sympathetic chain ganglia, also known as the sympathetic trunk ganglia or paravertebral ganglia, are a series of ganglia located bilaterally on either side of the spinal column. These ganglia serve as relay stations for the sympathetic nervous system. Preganglionic neurons originating in the spinal cord project their axons to the sympathetic chain ganglia. Within the ganglia, these preganglionic fibers synapse with postganglionic neurons.The postganglionic neurons of the sympathetic trunk...
The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...
Peripheral Nervous System: Ganglia and Nerves01:24

Peripheral Nervous System: Ganglia and Nerves

The Peripheral Nervous System (PNS) is a crucial component of the body's neural network, extending beyond the central nervous system (CNS) to bridge the gap between the CNS and the external environment. It encompasses nerves, ganglia, and sensory receptors.
Nerves
The nerve is a bundle of axons that serves as the communication highway in the PNS. Each nerve is ensheathed in a protective layer of connective tissue called the epineurium. This outermost layer safeguards the nerve and supports the...
Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla01:27

Sympathetic Pathways: Collateral Ganglia and Adrenal Medulla

The sympathetic pathways of the collateral ganglia and adrenal medulla serve unique but interconnected roles in the sympathetic response.
Collateral Ganglia
Sympathetic preganglionic axons reach the collateral ganglia along the route of splanchnic nerves. These nerves bypass the sympathetic trunk and communicate with sympathetic postganglionic neurons housed in the prevertebral ganglia. These ganglia supply the organs of the abdominopelvic cavity.
The greater splanchnic nerve, formed by the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Targeted long-read sequencing with adaptive sampling enables the integrated genomic and epigenomic profiling of imprinting disorders.

Scientific reports·2026
Same author

From Tissue Architecture To Genetic Signature: Artificial intelligence-based Analysis of Reticulin Framework and Clinical Variables Predicts Molecular Cluster in Paragangliomas.

Endocrine pathology·2026
Same author

Germline Non-CDKN2A Variants in Melanoma and Associated Hereditary Cancer Syndromes.

Diseases (Basel, Switzerland)·2025
Same author

LONG-NEXT: A new accurate and efficient NGS-based method for GBA1 analysis in Parkinson disease.

Parkinsonism & related disorders·2025
Same author

The Impact of the G6PD Gene Mutations in Patients with Chronic Hepatitis C Infection Treated with Direct-Acting Antivirals: A Multicenter Observational Study.

Genes·2024
Same author

Prevalence of Hyperkalemia and Familial Hyperkalemic Hypertension in 5100 Patients Referred to a Tertiary Hypertension Unit.

Hypertension (Dallas, Tex. : 1979)·2024
Same journal

Preface.

Advances in oto-rhino-laryngology·2020
Same journal

Future Advances in Neurolaryngology.

Advances in oto-rhino-laryngology·2020
Same journal

Structure, Function and Insertion of the Human Vocal Folds.

Advances in oto-rhino-laryngology·2020
Same journal

Laryngeal Reinnervation: The History and Where We Stand Now.

Advances in oto-rhino-laryngology·2020
Same journal

Neuromuscular Disease Affecting the Larynx.

Advances in oto-rhino-laryngology·2020
Same journal

Objective Measures of Stroboscopy and High-Speed Video.

Advances in oto-rhino-laryngology·2020
See all related articles

Related Experiment Video

Updated: Jun 4, 2026

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
08:57

Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

Published on: May 17, 2024

Hereditary paragangliomas.

Margarita Raygada, Barbara Pasini, Constantine A Stratakis

    Advances in Oto-Rhino-Laryngology
    |March 2, 2011
    PubMed
    Summary
    This summary is machine-generated.

    Hereditary paragangliomas (PGL) and pheochromocytomas (PCC) are linked to mutations in succinate dehydrogenase (SDH) genes and other genetic syndromes. Understanding these genetic links aids in risk assessment and prognosis for PGL and PCC.

    More Related Videos

    Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
    09:33

    Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

    Published on: August 25, 2023

    Related Experiment Videos

    Last Updated: Jun 4, 2026

    Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models
    08:57

    Identifying, Diagnosing, and Grading Malignant Peripheral Nerve Sheath Tumors in Genetically Engineered Mouse Models

    Published on: May 17, 2024

    Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor
    09:33

    Genetic Profiling and Genome-Scale Dropout Screening to Identify Therapeutic Targets in Mouse Models of Malignant Peripheral Nerve Sheath Tumor

    Published on: August 25, 2023

    Area of Science:

    • Neuro-oncology
    • Endocrinology
    • Genetics

    Background:

    • Paragangliomas (PGL) and pheochromocytomas (PCC) are rare neuroendocrine tumors.
    • Up to 35% of PGL and PCC cases have a hereditary basis.
    • Germline mutations in succinate dehydrogenase (SDH) genes (SDHD, SDHC, SDHB, SDHAF2/SDH5, SDHA) are frequently associated with familial PGL syndromes.

    Purpose of the Study:

    • To provide an overview of the genetics of PGL and PCC.
    • To emphasize genetic risk assessment, prevention, and prognosis for these rare tumors.
    • To discuss newly identified genes predisposing to PGL/PCC, such as TMEM127.

    Main Methods:

    • Review of genetic mutations associated with PGL and PCC.
    • Analysis of familial PGL syndromes (PGL1-4).
    • Inclusion of other associated genetic conditions like Von Hippel Lindau disease, MEN2, and NF1.

    Main Results:

    • Germline mutations in SDH subunits (SDHD, SDHC, SDHB, SDHAF2/SDH5, SDHA) are key genetic drivers.
    • Mutations in SDHB, SDHC, and SDHD are also linked to Carney-Stratakis syndrome (PGL/PCC with GISTs).
    • TMEM127 mutations represent a newly identified genetic risk factor for PGL/PCC.

    Conclusions:

    • Genetic factors play a significant role in the development of PGL and PCC.
    • Genetic testing and counseling are crucial for risk assessment, early detection, and personalized management.
    • Understanding the genetic landscape of PGL/PCC improves prognostic accuracy and informs preventative strategies.