Related Experiment Video
Updated: Jun 4, 2026
06:08
Immunofluorescent Labeling in Nasal Mucosa Tissue Sections of Allergic Rhinitis Rats via Multicolor Immunoassay
Published on: September 22, 2023
The links between chronic rhinosinusitis and asthma.
Michael N Pakdaman1, Amber Luong
1Department of Otorhinolaryngology-Head and Neck Surgery, Texas Sinus Institute, University of Texas Medical School at Houston, Houston, Texas 77030, USA.
Summary
New research highlights common pathogens like fungi and Staphylococcus aureus, and biomarkers such as nitric oxide and interleukin-17A, linking chronic rhinosinusitis (CRS) and asthma. These findings offer insights into the pathophysiology of these upper and lower airway diseases.
Area of Science:
- Immunology
- Pulmonology
- Otolaryngology
Background:
- Chronic rhinosinusitis (CRS) and asthma are prevalent conditions with overlapping clinical presentations.
- The atopic pathway has been an initial focus for understanding their relationship.
- The precise pathophysiology of CRS and asthma remains an active area of research.
Purpose of the Study:
- To review recent advancements in understanding the shared pathophysiology of CRS and asthma.
- To explore novel common pathogens and biomarkers implicated in both conditions.
- To discuss potential impacts on clinical management strategies.
Main Methods:
- Literature review of recent studies published within the past year.
- Analysis of research focusing on common pathogens and biomarkers in CRS and asthma.
- Synthesis of findings related to upper and lower airway disease interactions.
Main Results:
- Identification of fungi and Staphylococcus aureus as common pathogens in both CRS and asthma.
- Recognition of nitric oxide and interleukin-17A (IL-17A) as significant disease biomarkers.
- Emerging understanding of the role of these factors in the pathophysiology of both conditions.
Conclusions:
- Fungal stimuli and superantigen reactions may contribute to the pathogenesis of CRS and asthma.
- Biomarkers like nitric oxide and IL-17A offer potential explanations for the established link between these diseases.
- These discoveries may influence future treatment approaches for patients with comorbid CRS and asthma.
Related Concept Videos
01:28Asthma I: Introduction
Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
01:29Asthma-I: Introduction
Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
01:26Asthma-II: Pathophysiology and Classification
Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
01:20Asthma: Pathogenesis and Management
Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
01:24Asthma-III: Symptoms and Complications
Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
Classification of Asthma
01:24Chronic Obstructive Pulmonary Disease III: Chronic Bronchitis Features
Chronic bronchitis is a key phenotype of chronic obstructive pulmonary disease (COPD), characterized by airway-centered inflammation and mucus overproduction. It develops from long-term exposure to harmful particles or gases, most commonly cigarette smoke, which triggers a persistent inflammatory response.Cellular and Structural ChangesInflammation initially affects the large bronchi and later the smaller airways, with infiltration by immune cells, including neutrophils, macrophages, and...