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Related Experiment Video

Updated: Jun 4, 2026

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

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Published on: May 17, 2016

c-Myb in Smooth Muscle Cells.

M Simons¹, R D Rosenberg

¹Department of Biology, Massachusetis Institute of Technology, Cambridge, MA.

Methods in Molecular Medicine

|March 2, 2011

Summary

This summary is machine-generated.

The proto-oncogene c-myb, a homolog of viral oncogene v-myb, is conserved in eukaryotes. Human c-myb mRNA in thymus suggests a potential intermolecular recombination event in its formation.

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Last Updated: Jun 4, 2026

Identification of MyoD Interactome Using Tandem Affinity Purification Coupled to Mass Spectrometry

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Published on: May 17, 2016

Isolation of Primary Patient-specific Aortic Smooth Muscle Cells and Semiquantitative Real-time Contraction Measurements In Vitro

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Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos

Chromatin Immunoprecipitation Assay for Tissue-specific Genes using Early-stage Mouse Embryos

Published on: April 29, 2011

Area of Science:

Molecular Biology
Genetics
Oncology

Background:

The c-myb gene is a proto-oncogene and a cellular homolog of the viral oncogene v-myb.
v-myb is found in avian acute leukemia viruses, including avian myeloblastosis virus (AMV) and E26 leukemia virus.
The myb gene is highly conserved across eukaryotic species.

Purpose of the Study:

To investigate the genomic structure and expression of the c-myb gene.
To explore potential mechanisms involved in the formation of mature c-myb protein in humans.

Main Methods:

Analysis of gene structure and conservation.
Mapping of the human c-myb gene locus.
Detection and characterization of c-myb mRNA transcripts in human thymus.

Main Results:

The c-myb gene typically comprises 15 exons spanning over 35 kb of genomic DNA.
The human c-myb gene locus is mapped to chromosome 6 (6q22-23).
c-myb mRNA in human thymus shows transcripts originating from chromosome 17 (17q25).

Conclusions:

The findings suggest a potential intermolecular recombinant event in the formation of mature c-myb protein in human thymus.
The conservation of the myb gene highlights its fundamental biological importance.
Understanding c-myb gene expression is crucial for research in leukemia and cancer biology.