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Updated: Jun 4, 2026
09:04
Sequence-specific and Selective Recognition of Double-stranded RNAs over Single-stranded RNAs by Chemically Modified Peptide Nucleic Acids
Published on: September 21, 2017
Comparative pharmacokinetics of antisense oligonucleotides
1Hybridon, Inc., Worcester, MA.
Methods in Molecular Medicine
|March 2, 2011
Summary
Antisense oligonucleotides offer targeted gene silencing for treating viral infections, cancers, and genetic disorders. These therapeutic agents bind to specific gene sequences or messenger RNA (mRNA) to inhibit disease-associated gene expression.
Area of Science:
- Molecular Biology
- Pharmacology
- Genetics
Background:
- Antisense oligonucleotides (ASOs) are a novel therapeutic class.
- ASOs target disease-associated gene expression via sequence-specific binding.
- Early work demonstrated ASO inhibition of viral replication.
Purpose of the Study:
- To highlight the therapeutic potential of antisense oligonucleotides.
- To review the mechanism of gene expression inhibition by ASOs.
- To discuss the application of ASOs in various disease contexts.
Main Methods:
- Utilizing Watson-Crick base pairing for oligonucleotide-target hybridization.
- Sequence-specific binding to gene or messenger RNA (mRNA).
- Demonstration of gene expression modulation.
Main Results:
- Antisense oligonucleotides effectively inhibit gene expression.
- ASOs show promise in modulating gene expression for therapeutic purposes.
- The field has seen significant advancements since initial discoveries.
Conclusions:
- Antisense oligonucleotides represent a promising therapeutic strategy.
- Sequence-specific gene inhibition is achievable with ASOs.
- ASOs have broad applications for treating viral infections, cancers, and genetic disorders.
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