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Updated: Jun 4, 2026

MALDI Imaging Mass Spectrometry of Neuropeptides in Parkinson's Disease
Published on: February 14, 2012
ECT in a patient with Parkinson's disease and schizophrenia, with dopamine transporter visualisation using
Paloma Fernández-Corcuera1, Salvatore Aguilar, Víctor Viçens
1Aguts Unit, Benito Menni Hospital, c/Antoni Pujades s/n. Sant Boi de Llobregat, 08830, Barcelona, Spain. paloma-cor@hotmail.com
Abstract:
A 58-year old woman with chronic schizophrenia developed worsening parkinsonian symptoms over the previous 6 years, and was eventually diagnosed as having Parkinson's disease. Antipsychotics were stopped because they worsened these symptoms. Antiparkinsonian treatment led to a significant increase in delusions and behavioural disorganisation. The patient underwent electroconvulsive-therapy which improved both her psychiatric and motor symptoms. After treatment, 123I-Ioflupane uptake was mildly increased in the left caudate nucleus, but uptake in right caudate nucleus was lower than in a pretreatment scan.
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