Related Experiment Video

Updated: Jun 4, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Chemical synthesis and biological evaluation of the englerin analogues

Kok Ping Chan1, David Y-K Chen

  • 1Chemical Synthesis Laboratory at Biopolis, Institute of Chemical and Engineering Sciences (ICES), Agency for Science, Technology and Research (A*STAR), 11 Biopolis Way, The Helios Block #03-08, 138667, Singapore.

Chemmedchem
|March 2, 2011
PubMed
Abstract

No abstract available in PubMed .

More Related Videos

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
10:24

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

Published on: January 27, 2026

Related Experiment Videos

Last Updated: Jun 4, 2026

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay
05:17

Functionalized Spirocyclic Heterocycle Synthesis and Cytotoxicity Assay

Published on: February 9, 2021

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors
09:45

Modification and Functionalization of the Guanidine Group by Tailor-made Precursors

Published on: April 27, 2017

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources
10:24

A Fluorescence-based Protocol for Preliminary Screening of Protein Synthesis Inhibitors from Natural Sources

Published on: January 27, 2026

Related Concept Videos

Adrenergic Agonists: Chemistry and Structure-Activity Relationship01:16

Adrenergic Agonists: Chemistry and Structure-Activity Relationship

Adrenergic agonists' structure-activity relationship (SAR) determines their selectivity and efficacy. These agonists comprise a phenylethylamine moiety with an aromatic ring and an ethylamine side chain.
Aromatic ring substitutions: Substituting the aromatic ring with –OH groups at positions 3 and 4 yields catecholamines (e.g., epinephrine), which have a high affinity for adrenoceptors. Hydrogen bonding between –OH groups and receptors enhances adrenergic activity.
Separation of the aromatic...
Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction01:26

Synthesis of α-Substituted Carbonyl Compounds: The Stork Enamine Reaction

α-Substituted ketones or aldehydes can be synthesized from enamines by the Stork enamine reaction, named after its pioneer Gilbert Stork. Enamines are useful synthetic intermediates where the lone pair on nitrogen is in conjugation with the C=C bond. They resemble enolate ions, as the resonance forms of both species have a nucleophilic α carbon.

Articles linked to this work by shared authors, journal, and citation graph.

Stereo-Controlled Synthesis of Vicinal Tertiary Carbinols: Application in the Synthesis of a Diol Substructure of Zaragozic Acid, Pactamycin and Ryanodol.

Chemistry (Weinheim an der Bergstrasse, Germany)·2023

Synthesis of phosphine oxide based amphiphilic molecules via ring-opening Wittig olefination of a macrocyclic phosphoranylidene and their property study as non-ionic surfactants.

RSC advances·2022

Late-stage and strain-accelerated oxidation enabled synthesis of haouamine A.

Chemical science·2020

A Desymmetrization-Based Total Synthesis of Reserpine.

Angewandte Chemie (International ed. in English)·2018

A Local-Desymmetrization-Based Divergent Synthesis of Quinine and Quinidine.

Angewandte Chemie (International ed. in English)·2018

A desymmetrization-based approach to morphinans: application in the total synthesis of oxycodone.

Chemical communications (Cambridge, England)·2018

Beyond Single-Target Therapy: Dual-Acting Cannabinoid Type-2 Receptor Modulation in Neurological Disorders.

ChemMedChem·2026

A Molecular Rationale for Tailoring the Growth Mechanisms of Biomimetic Calcium Oxalates: Guides to Simplified Proxies of Renal Stones?

ChemMedChem·2026

Multitarget Drug Design for Cardiovascular Disease: Bridging Chemistry and Medicine.

ChemMedChem·2026

Searching for Novel COVID19 Treatments: Towards Covalent TMPRSS2 Inhibitors.

ChemMedChem·2026

Network Pharmacology in Drug Discovery: Current Advances, Challenges, and Future Directions Toward Precision Medicine.

ChemMedChem·2026

Synthesis, Moleculer Modeling, and Carbonic Anhydrase Inhibitor Effects of Novel 1-(1-benzyl-2-oxoindolin-3-ylidene)-4-(3-sulfamoylphenyl)thiosemicarbazides.

ChemMedChem·2026
See all related articles
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies
Jove
Visualize
Contact Us