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Updated: Jun 4, 2026

Development of Stem Cell-derived Antigen-specific Regulatory T Cells Against Autoimmunity
Published on: November 8, 2016
Bcl-2-regulated cell death signalling in the prevention of autoimmunity
D Tischner1, C Woess, E Ottina
1Division of Developmental Immunology, BIOCENTER, Medical University Innsbruck, Innsbruck, Austria.
Abstract:
Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention.
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