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Published on: October 31, 2012
Histologic and histomorphometric evaluation of an allograft stem cell-based matrix sinus augmentation procedure
Aron Gonshor1, Bradley S McAllister, Stephen S Wallace
1Faculty of Dentistry, McGill University, Montreal, Quebec, Canada. arongonshor@gmail.com
Summary
Allograft cellular bone matrix significantly enhances vital bone formation for sinus augmentation compared to conventional allografts. This cellular grafting approach may allow for faster dental implant placement.
Area of Science:
- Oral surgery
- Regenerative medicine
- Dental implantology
Background:
- Dental implant success is linked to sinus augmentation.
- Grafting materials other than autogenous bone require long healing times (6-9 months).
- A need exists for bone grafting techniques that avoid autogenous bone harvesting and shorten healing periods.
Purpose of the Study:
- To compare bone formation after sinus augmentation using allograft cellular bone matrix (ACBM) versus conventional allograft (CA).
- To evaluate the efficacy of ACBM in promoting bone regeneration for dental implant procedures.
Main Methods:
- Sinus augmentation procedures were performed.
- Bone formation was assessed using histomorphometric analysis.
- ACBM and CA were compared for vital bone and residual graft content.
Main Results:
- ACBM grafts showed significantly higher vital bone content (32.5%) compared to CA (18.3%) at an average healing time of 3.7 months (P=.003).
- ACBM grafts had significantly lower residual graft content (4.9%) compared to CA (25.8%) (P=.002).
- Statistically significant differences were observed between ACBM and CA for both vital and residual bone.
Conclusions:
- ACBM demonstrates superior bone regenerative capacity compared to CA in sinus augmentation.
- The accelerated bone formation with ACBM may reduce the time to dental implant placement.
- Cellular bone grafting offers a promising alternative for efficient sinus floor elevation.
